Vibsane-Type Diterpenoids from Viburnum odoratissimum and Their Cytotoxic and HSP90 Inhibitory Activities

被引：16

作者：

Zhu, Qin-Feng ^{[1
,2
]}

Qi, Yan-Yan ^{[1
,2
]}

Zhang, Zhi-Jun ^{[1
,2
]}

Fan, Min ^{[1
,2
]}

Bi, Ran ^{[1
,2
]}

Su, Jia ^{[1
]}

Wu, Xing-De ^{[1
]}

Shao, Li-Dong ^{[1
]}

Zhao, Qin-Shi ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2018年 / 15卷 / 05期

基金：

中国国家自然科学基金;

关键词：

vibsane-type diterpenoids; Viburnum odoratissimum; cytotoxicity; HSP90; inhibitor; BIOLOGICAL-ACTIVITIES; LEAVES; AWABUKI;

D O I：

10.1002/cbdv.201800049

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four new vibsane-type diterpenoids, vibsanol I (1), 15-hydroperoxyvibsanol A (2), 14-hydroperoxyvibsanol B (3), 15-O-methylvibsanin U (4), and a new natural product, 5,6-dihydrovibsanin B (5), as well as six known analogues, were isolated from the twigs and leaves of Viburnum odoratissimum. Their structures were elucidated by spectroscopic analyses and chemical derivatization method. All compounds showed different levels of cytotoxicity against five cell lines (HL-60, A-549, SMMC-7721, MCF-7, and SW480). Remarkably, 14,18-O-diacetyl-15-O-methylvibsanin U (4a) showed significant cytotoxicity against HL-60, A-549, SMMC-7721, MCF-7, and SW480, with IC50 values of 0.15 +/- 0.01, 0.69 +/- 0.01, 0.41 +/- 0.02, 0.75 +/- 0.03, and 0.48 +/- 0.03m, respectively. In addition, vibsanin K (10) was identified as a HSP90 inhibitor with an IC50 value of 19.16m.

引用

页数：9

共 19 条

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