Combined Pulmonary Fibrosis and Emphysema: 3D Time-resolved MR Angiographic Evaluation of Pulmonary Arterial Mean Transit Time and Time to Peak Enhancement

被引：33
作者：
Sergiacomi, Gianluigi [1 ]
Bolacchi, Francesca [1 ]
Cadioli, Marcello [4 ]
Angeli, Maria Luigia [1 ]
Fucci, Francesco [1 ]
Crusco, Sonia [1 ]
Rogliani, Paola [2 ]
Pezzuto, Gabriella [2 ]
Romeo, Francesco [3 ]
Mariano, Enrica [3 ]
Simonetti, Giovanni [1 ]
机构：
[1] Univ Hosp Policlin Tor Vergata, Dept Diagnost & Mol Imaging, I-00133 Rome, Italy
[2] Univ Hosp Policlin Tor Vergata, Dept Internal Med, Div Pulm, I-00133 Rome, Italy
[3] Univ Hosp Policlin Tor Vergata, Dept Internal Med, Div Cardiol, I-00133 Rome, Italy
[4] Philips Healthcare, Monza, Italy
来源：
RADIOLOGY | 2010年 / 254卷 / 02期
关键词：
LUNG-DISEASE; HYPERTENSION; PERFUSION; ECHOCARDIOGRAPHY; RESOLUTION; QUANTIFICATION; EXPERIENCE; DIAGNOSIS;
D O I：
10.1148/radiol.09081546
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Purpose: To correlate conventional invasive pressure indexes of pulmonary circulation with pulmonary first-order arterial mean transit time (MTT) and time to peak enhancement (TTP) measured by means of three-dimensional time-resolved magnetic resonance (MR) angiography in patients with combined pulmonary fibrosis and emphysema (CPFE). Materials and Methods: The study was institutional review board approved. All subjects involved in the study provided written informed consent. Eighteen patients with CPFE were enrolled in this study. Thirteen healthy individuals matched for age and sex served as control subjects. Three-dimensional time-resolved MR angiography was performed by using a 3.0-T MR imager. Regions of interest (ROIs) were drawn manually on first-order pulmonary arteries. Within the ROIs, signal intensity-versus-time curves reflecting the first pass of the contrast agent bolus in the pulmonary vessels were obtained. MTT and TTP were calculated. Pulmonary arterial pressure and pulmonary capillary wedge pressure were measured with a double-lumen, balloon-tipped catheter that was positioned in the pulmonary artery. The mean pulmonary arterial pressure (mPAP) and the pulmonary vascular resistance (PVR) were determined. Results: MTT and TTP values were prolonged significantly in patients with CPFE compared with those in the control subjects (P < .001). Mean TTP and mean MTT correlated directly with mPAP and PVR index (P < .005). At multiple linear regression analysis, MTT was the only factor independently associated with PVR index and mPAP. Conclusion: Three-dimensional time-resolved MR angiography enables determination of pulmonary hemodynamic parameters that correlate significantly with the pulmonary hemodynamic parameters obtained with invasive methods and may represent a complementary tool for evaluating pulmonary hypertension in patients with CPFE. (C) RSNA, 2010
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收藏
页码：601 / 608
页数：8
相关论文
共 39 条
  • [1] Echocardiographic assessment of pulmonary hypertension in patients with advanced lung disease
    Arcasoy, SM
    Christie, JD
    Ferrari, VA
    Sutton, MS
    Zisman, DA
    Blumenthal, NP
    Pochettino, A
    Kotloff, RM
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2003, 167 (05) : 735 - 740
  • [2] Pulmonary arterial hypertension - The key role of echocardiography
    Bossone, E
    Bodini, BD
    Mazza, A
    Allegra, L
    [J]. CHEST, 2005, 127 (05) : 1836 - 1843
  • [3] Range of tricuspid regurgitation velocity at rest and during exercise in normal adult men: Implications for the diagnosis of pulmonary hypertension
    Bossone, E
    Rubenfire, M
    Bach, DS
    Ricciardi, M
    Armstrong, WF
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1999, 33 (06) : 1662 - 1666
  • [4] Campeau N G, 2001, Top Magn Reson Imaging, V12, P183, DOI 10.1097/00002142-200106000-00005
  • [5] Cassandro R, 2006, SARCOIDOSIS VASC DIF, V23, P163
  • [6] Haemodynamic evaluation of pulmonary hypertension
    Chemla, D
    Castelain, V
    Hervé, P
    Lecarpentier, Y
    Brimioulle, S
    [J]. EUROPEAN RESPIRATORY JOURNAL, 2002, 20 (05) : 1314 - 1331
  • [7] Combined pulmonary fibrosis and emphysema: a distinct underrecognised entity
    Cottin, V
    Nunes, H
    Brillet, PY
    Delaval, P
    Devouassoux, G
    Tillie-Leblond, I
    Israel-Biet, D
    Court-Fortune, I
    Valeyre, D
    Cordier, JF
    [J]. EUROPEAN RESPIRATORY JOURNAL, 2005, 26 (04) : 586 - 593
  • [8] Anti-elastin autoantibodies are not present in combined pulmonary fibrosis and emphysema
    Cottin, V.
    Fabien, N.
    Khouatra, C.
    Moreira, A.
    Cordier, J-F.
    [J]. EUROPEAN RESPIRATORY JOURNAL, 2009, 33 (01) : 219 - 221
  • [9] ATS/ERS international multidisciplinary consensus classification of the idiopathic interstitial pneumonias
    Demedts, M
    Costabel, U
    [J]. EUROPEAN RESPIRATORY JOURNAL, 2002, 19 (05) : 794 - 796
  • [10] Effect of inspiratory and expiratory breathhold on pulmonary perfusion - Assessment by pulmonary perfusion magnetic resonance Imaging
    Fink, C
    Ley, S
    Risse, F
    Eichinger, M
    Zaporozhan, J
    Buhmann, R
    Puderbach, M
    Plathow, C
    Kauczor, HU
    [J]. INVESTIGATIVE RADIOLOGY, 2005, 40 (02) : 72 - 79
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