Lung Adenocarcinoma with Cheek Dysesthesia as an Initial Symptom: A Case Report and Literature Review

被引:5
作者
Bandoh, Nobuyuki [1 ]
Ichikawa, Haruyuki [1 ,4 ]
Asahi, Atsuyoshi [2 ]
Kono, Michihisa [1 ,4 ]
Harabuchi, Shohei [4 ]
Sato, Ryosuke [1 ]
Uemura, Akihiro [1 ]
Goto, Takashi [1 ]
Yamaguchi, Tomomi [3 ]
Kato, Yasutaka [3 ]
Furukawa, Hironori [3 ]
Takei, Hidehiro [4 ]
Harabuchi, Yasuaki [5 ]
机构
[1] Hokuto Hosp, Dept Otolaryngol Head & Neck Surg, Inadacho Kisen 7-5, Obihiro, Hokkaido 0800833, Japan
[2] Hokuto Hosp, Dept Gen Med, Obihiro, Hokkaido, Japan
[3] Hokuto Hosp, Lab Canc Med Sci, Dept Biol & Genet, Obihiro, Hokkaido, Japan
[4] Asahikawa Med Univ Hosp, Dept Surg Pathol, Asahikawa, Hokkaido, Japan
[5] Asahikawa Med Univ, Dept Otolaryngol Head & Neck Surg, Asahikawa, Hokkaido, Japan
来源
CASE REPORTS IN ONCOLOGY | 2019年 / 12卷 / 02期
关键词
Lung adenocarcinoma; Sphenoid bone; Metastasis; Trigeminal nerve; Epidermal growth factor receptor (EGFR); METASTASIS; CANCER; SURVIVAL; SINUS; BONE;
D O I
10.1159/000502053
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Metastasis from lung carcinoma to the sphenoid bone is rare. Patients with symptoms related to sphenoid bone metastasis as the initial presentation of carcinoma are thus also rare. Herein, we report the case of a patient presenting with only cheek dysesthesia as the first sign of lung adenocarcinoma. The 74-year-old woman presented with a 2-month history of left cheek dysesthesia. CT showed a tumor around 2.5 cm in diameter with heterogeneous enhancement of the central focus at the left foramen rotundum in the sphenoid bone. We endoscopically biopsied the tumor through the left sphenoid sinus. Results of histologic examination were consistent with lung adenocarcinoma. FDG-PET/CT analysis demonstrated lung carcinoma that had already metastasized to mediastinal lymph nodes and multiple bones, such as the ribs and lumbar vertebras, in addition to the sphenoid bone. As EGFR gene mutation (p.L858R) was identified, the patient was treated with oral gefinitib. This treatment proved quite effective, and the patient remains alive without tumor growth as of 18 months. (C) 2019 The Author(s) Published by S. Karger AG, Basel
引用
收藏
页码:650 / 656
页数:7
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