Nonapoptotic functions of caspases: caspases as regulatory molecules for immunity and cell-fate determination

被引：155

作者：

Kuranaga, Erina ^{[1
]}

Miura, Masayuki ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Dept Genet, Bunkyo Ku, Tokyo 1130033, Japan

来源：

TRENDS IN CELL BIOLOGY | 2007年 / 17卷 / 03期

关键词：

D O I：

10.1016/j.tcb.2007.01.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Caspases are a family of cysteine proteases that are highly conserved in multicellular organisms and function as central regulators of apoptosis. Recent investigations in Caenorhabditis elegans, Drosophila and mice suggest that caspases also function as regulatory molecules for immunity and cell-fate determination. Here, we review genetic studies of nonapoptotic functions of caspases and discuss the regulatory mechanisms of caspases for executing nonapoptotic functions.

引用

页码：135 / 144

页数：10

共 80 条

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