Application of biocatalysis and biotransformations to the synthesis of pharmaceuticals

被引：112
作者：
Zaks, A
Dodds, DR
机构：
[1] Schering-Plough Research Institute, Biotransformations Group, Kenilworth, NJ 07033
来源：
DRUG DISCOVERY TODAY | 1997年 / 2卷 / 12期
关键词：
D O I：
10.1016/S1359-6446(97)01078-7
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The application of biologically derived catalysts to the synthesis of pharmaceuticals has grown rapidly in recent years, This review covers examples of isolated enzymes and microorganisms used as catalysts for the synthesis of pharmacologically valuable materials, on both a laboratory and a commercial scale.
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收藏
页码：513 / 531
页数：19
相关论文
共 140 条
[71]   OVERPRODUCTION OF CMP-SIALIC ACID SYNTHETASE FOR ORGANIC-SYNTHESIS [J].
LIU, JLC ;
SHEN, GJ ;
ICHIKAWA, Y ;
RUTAN, JF ;
ZAPATA, G ;
VANN, WF ;
WONG, CH .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (10) :3901-3910
[72]   ENZYMES IN THE SYNTHESIS OF CHIRAL DRUGS [J].
MARGOLIN, AL .
ENZYME AND MICROBIAL TECHNOLOGY, 1993, 15 (04) :266-280
[73]   ENZYME-CATALYZED REGIOSELECTIVE ACYLATION OF CASTANOSPERMINE [J].
MARGOLIN, AL ;
DELINCK, DL ;
WHALON, MR .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (08) :2849-2854
[74]   Novel crystalline catalysts [J].
Margolin, AL .
TRENDS IN BIOTECHNOLOGY, 1996, 14 (07) :223-230
[75]  
Matsumoto K, 1993, Bioprocess Technol, V16, P67
[76]   PREPARATION OF OPTICALLY-ACTIVE 1-ACETOXY-2-ARYLOXYPROPIONITRILES AND ITS APPLICATION TO A FACILE SYNTHESIS OF (S)-(-)-PROPRANOLOL [J].
MATSUO, N ;
OHNO, N .
TETRAHEDRON LETTERS, 1985, 26 (45) :5533-5534
[77]  
MEGGES R, 1990, MOL MECH, V3, P204
[78]  
MICHELBRIAND Y, 1991, Patent No. 12326
[79]   ENANTIOSELECTIVE ENZYMATIC-SYNTHESIS OF THE ANTIVIRAL AGENT LAMIVUDINE (3TC(TM)) [J].
MILTON, J ;
BRAND, S ;
JONES, MF ;
RAYNER, CM .
TETRAHEDRON LETTERS, 1995, 36 (38) :6961-6964
[80]   Directed evolution of a para-nitrobenzyl esterase for aqueous-organic solvents [J].
Moore, JC ;
Arnold, FH .
NATURE BIOTECHNOLOGY, 1996, 14 (04) :458-467
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