Application of biocatalysis and biotransformations to the synthesis of pharmaceuticals

被引:112
作者
Zaks, A
Dodds, DR
机构
[1] Schering-Plough Research Institute, Biotransformations Group, Kenilworth, NJ 07033
关键词
D O I
10.1016/S1359-6446(97)01078-7
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The application of biologically derived catalysts to the synthesis of pharmaceuticals has grown rapidly in recent years, This review covers examples of isolated enzymes and microorganisms used as catalysts for the synthesis of pharmacologically valuable materials, on both a laboratory and a commercial scale.
引用
收藏
页码:513 / 531
页数:19
相关论文
共 140 条
[11]  
BRIGGS BS, 1994, NEW J CHEM, V18, P425
[12]  
CAMBIAGHI S, Patent No. 496993
[13]  
Charney W., 1967, MICROBIAL TRANSFORMA
[14]   ASYMMETRIC BIOREDUCTION OF A BETA-KETOESTER TO (R)-BETA-HYDROXYESTER BY THE FUNGUS MORTIERELLA-ALPINA MF-5534 [J].
CHARTRAIN, M ;
ARMSTRONG, J ;
KATZ, L ;
KELLER, J ;
MATHRE, D ;
GREASHAM, R .
JOURNAL OF FERMENTATION AND BIOENGINEERING, 1995, 80 (02) :176-179
[15]  
CHAUVIERE G, 1981, CR ACAD SCI II, V293, P501
[16]   BIOCATALYTIC RESOLUTION OF DL-PROPRANOLOL - A SUCCESSFUL EXAMPLE OF COMPUTER-AIDED SUBSTRATE DESIGN [J].
CHEN, CS ;
GOU, DM ;
SHIEH, WR ;
LIU, YC .
TETRAHEDRON, 1993, 49 (16) :3281-3290
[17]   A CONVENIENT CHEMOENZYMATIC SYNTHESIS OF (R)-(CHLOROMETHYL)OXIRANE AND (S)-(CHLOROMETHYL)OXIRANE [J].
CHEN, CS ;
LIU, YC ;
MARSELLA, M .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1990, (09) :2559-2561
[18]   Asymmetric synthesis of substituted 2-azaspiro[3.5]nonan-1-ones: An enantioselective synthesis of the cholesterol absorption inhibitor (+)-SCH 54016 [J].
Chen, LY ;
Zaks, A ;
Chackalamannil, S ;
Dugar, S .
JOURNAL OF ORGANIC CHEMISTRY, 1996, 61 (23) :8341-8343
[19]   CHEMOENZYMATIC SYNTHESIS OF BOTH ENANTIOMERS OF BACLOFEN [J].
CHENEVERT, R ;
DESJARDINS, M .
TETRAHEDRON LETTERS, 1991, 32 (34) :4249-4250
[20]  
CHIANG SJ, Patent No. 5516679