Process design involves process mean and process tolerance determination. Process mean determination is finding the best settings for product quality, without affecting manufacturing cost. However, process tolerance determination is a manufacturing process selection which generally affects manufacturing cost and product quality. In this study, asymmetric quality loss is considered in measuring product quality, and tolerance cost is adopted in representing manufacturing cost. To reflect the combined effect of process mean and process tolerance completely, failure cost is added to the category of manufacturing cost. Then, based on the sum of these three costs, a simultaneous optimization of process mean and process tolerance is determined for process planning in the early stages of development.