Modular design of artificial transcription factors

被引：82
作者：
Ansari, AZ
Mapp, AK
机构：
[1] Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA
[2] Univ Wisconsin, Genome Ctr, Madison, WI 53706 USA
[3] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
[4] Univ Michigan, Dept Med Chem, Ann Arbor, MI 48109 USA
来源：
CURRENT OPINION IN CHEMICAL BIOLOGY | 2002年 / 6卷 / 06期
关键词：
D O I：
10.1016/S1367-5931(02)00377-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Eukaryotic transcription factors are composed of interchangeable modules. This has led to the design of a wide variety of modular artificial transcription factors (ATFs) that can stimulate or inhibit the expression of targeted genes. The ability to regulate the expression of any targeted gene using a 'programmable' ATF offers a powerful tool for functional genomics and bears tremendous promise in developing the field of transcription-based therapeutics.
引用
收藏
页码：765 / 772
页数：8
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