Association of apolipoproteins C-I, C-II, C-III and E with coagulation markers and venous thromboembolism risk

被引:16
作者
Orsi, Fernanda A. [1 ,2 ]
Lijfering, Willem M. [2 ,3 ]
Van der Laarse, Arnoud [4 ,5 ]
Ruhaak, L. Renee [4 ]
Rosendaal, Frits R. [2 ]
Cannegieter, Suzanne C. [2 ,3 ,6 ]
Cobbaert, Christa [4 ]
机构
[1] Univ Estadual Campinas, UNICAMP, Sch Med Sci, Dept Clin Pathol, Campinas, SP, Brazil
[2] Leiden Univ, Med Ctr, Dept Clin Epidemiol, POB 9600, NL-2300 RC Leiden, Netherlands
[3] Leiden Univ, Med Ctr, Einthoven Lab Expt Vasc Med, Leiden, Netherlands
[4] Leiden Univ, Med Ctr, Dept Clin Chem & Lab Med, Leiden, Netherlands
[5] Leiden Univ, Med Ctr, Dept Cardiol, Leiden, Netherlands
[6] Leiden Univ, Med Ctr, Sect Thrombosis & Hemostasis, Dept Internal Med, Leiden, Netherlands
来源
CLINICAL EPIDEMIOLOGY | 2019年 / 11卷
基金
巴西圣保罗研究基金会;
关键词
thrombosis; proteomics; lipids; cholesterol; coagulation; risk factors; RECEPTOR-RELATED PROTEIN; ISCHEMIC-HEART-DISEASE; VON-WILLEBRAND-FACTOR; CLOTTING FACTOR-VIII; PLASMA-LEVELS; CARDIOVASCULAR EVENTS; MYOCARDIAL-INFARCTION; HDL CHOLESTEROL; TISSUE FACTOR; THROMBOSIS;
D O I
10.2147/CLEP.S196266
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Purpose: Apolipoproteins C-I, C-II, C-III and E have been associated with risk of arterial thrombotic diseases. We investigated whether these apolipoproteins have prothrombotic properties and are associated with risk of venous thromboembolism (VTE). Patients and methods: A total of 127 VTE patients and 299 controls were randomly selected from the Multiple Environmental and Genetic Assessment of Risk Factors for Venous Thrombosis study (1999-2004), in the Netherlands. The apolipoproteins were quantified using mass spectrometry (LC/MS/MS), and their levels were analyzed as continuous variable (per SD increase). Results: In controls, increases in levels of apolipoproteins were associated with increases in levels of vitamin K-dependent factors, factor XI, antithrombin and clot lysis time. Additionally, increasing apolipoproteins C-III and E levels were associated with higher factor VIII and von Willebrand factor levels. Levels of C-reactive protein were not associated with any apolipoprotein. The age-and sex-adjusted odds ratios of apolipoproteins E, C-III, CII and CI to the risk of venous thrombosis were 1.21 (95% CI, 0.98-1.49), 1.19 (95% CI, 0.99-1.44), 1.24 (95% CI, 0.95-1.61) and 1.06 (95% CI, 0.87-1.30) per SD increase, respectively. These odds ratios did not attenuate after adjustments for statin use, estrogen use, BMI, alcohol use, and self-reported diabetes. Conclusions: Levels of apolipoproteins C-I, C-II, C-III and E are associated with those of several coagulation factors. However, whether these apolipoproteins are also associated with an increased risk of VTE remains to be established.
引用
收藏
页码:625 / 633
页数:9
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