Synthesis and pharmacological evaluation of some 3-(4-methylphenyl)-2-substituted amino-3H-quinazolin-4-ones as analgesic and anti-inflammatory agents

被引:16
作者
Alagarsamy, Veerachamy
Shankar, Durairaj
Murugan, Muthuvel
Ahmed Siddiqui, Anees
Rajesh, Ramadoss
机构
[1] Arulmigu Kalasalingam Coll Pharm, Med Chem Res Lab, Anand Nagar, Krishnankovil, India
[2] SASTRA Deemed Univ, Dept Pharm, CARISM, Thirumalaisamudram, Thanjavur, India
[3] Hamdard Univ, Dept Pharmaceut Chem, New Delhi, India
关键词
analgesic; anti-inflammatory; quinazoline;
D O I
10.1002/ardp.200600189
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A variety of 3-(4-methyl phenyl)-2-substituted amino-3H-quinazolin-4-ones were synthesized by reacting the amino group of 2-hydrazino-3-(4-methyl phenyl)-3H-quinazolin-4-one with a variety of aldehydes and ketones. The starting material 2-hydrazino-3-(4-methyl phenyl)-3H-quinazolin-4-one was synthesized from 4-methyl aniline. The title compounds were investigated for analgesic, anti-inflammatory, and ulcerogenic index activities. While the test compounds exhibited significant activity, compounds A1, A2, and A3 showed more potent analgesic activity and the compound A3 showed more potent anti-inflammatory activity when compared to the reference standard diclofenac sodium. Interestingly, the test compounds showed only mild ulcerogenic potential when compared to aspirin.
引用
收藏
页码:41 / 46
页数:6
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