Berberine impairs coxsackievirus B3-induced myocarditis through the inhibition of virus replication and host pro-inflammatory response

被引：14
作者：
Dai, Qian [1 ]
He, Xiaomei [1 ]
Yu, Hua [1 ]
Bai, Ying [2 ]
Jiang, Lu [1 ]
Sheng, Halei [1 ]
Peng, Jin [1 ]
Wang, Maolin [1 ]
Yu, Jiang [3 ]
Zhang, Kebin [1 ]
机构：
[1] Third Mil Med Univ, Army Med Univ, Xinqiao Hosp, Clin Med Res Ctr, Chongqing 400037, Peoples R China
[2] Third Mil Med Univ, Army Med Univ, Southwest Hosp, Dept Endocrinol & Metab, Chongqing, Peoples R China
[3] Third Mil Med Univ, Army Med Univ, Xinqiao Hosp, Dept Outpatient, Chongqing 400037, Peoples R China
来源：
JOURNAL OF MEDICAL VIROLOGY | 2021年 / 93卷 / 06期
基金：
中国国家自然科学基金;
关键词：
anti‐ CVB3; activity; berberine; coxsackievirus B3; viral myocarditis; B3; REPLICATION; INFECTION;
D O I：
10.1002/jmv.26747
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Berberine (BBR), an isoquinoline alkaloid isolated from Rhizoma coptidis, is reported to possess antiviral activity. Our previous study has shown that BBR alleviates coxsackievirus B3 (CVB3) replication in HeLa cells. However, the anti-CVB3 activity of BBR is still unclear in vivo. In this study, we explored the effect of BBR on CVB3-induced viral myocarditis in mice. These results demonstrated the beneficial effect of BBR on alleviating CVB3-induced myocarditis in vivo, which sheds new light on the utility of BBR as a therapeutic strategy against CVB3-induced viral myocarditis.
引用
收藏
页码：3581 / 3589
页数：9
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