Bitter Taste Receptors and Their Cells

被引：14

作者：

Behrens, Maik ^{[1
]}

Reichling, Claudia ^{[1
]}

Batram, Claudia ^{[1
]}

Brockhoff, Anne ^{[1
]}

Meyerhof, Wolfgang ^{[1
]}

机构：

[1] German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Genet, D-14558 Nuthetal, Germany

来源：

INTERNATIONAL SYMPOSIUM ON OLFACTION AND TASTE | 2009年 / 1170卷

关键词：

bitter taste receptor; G protein-coupled receptors; TAS2R; N-GLYCOSYLATION; EXPRESSION; GENE; SENSITIVITY; STIMULI; FAMILY; RATS; PHENYLTHIOCARBAMIDE; IDENTIFICATION; DISCRIMINATE;

D O I：

10.1111/j.1749-6632.2009.03897.x

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The molecular basis of human bitter taste perception is an area of intense research. Only 25 G protein-coupled receptors belonging to the hTAS2R gene family face the challenge to detect thousands of structurally different bitter compounds, most of which are plant metabolites. Since many natural bitter compounds are highly toxic, whereas others are part of our daily diets, bitter taste was crucial during evolution and still most likely affects our food selection. The article presented here addresses biosynthesis, functional analyses of TAS2Rs and TAS2R variants, as well as gustatory expression of hTAS2R genes.

引用

页码：111 / 115

页数：5

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