Siah Proteins: Novel Drug Targets in the Ras and Hypoxia Pathways

被引：72

作者：

House, Colin M. ^{[1
]}

Moeller, Andreas ^{[1
,2
]}

Bowtell, David D. L. ^{[1
,2
]}

机构：

[1] Peter MacCallum Canc Ctr, Canc Genom & Genet Lab, Melbourne, Vic, Australia

[2] Univ Melbourne, Dept Biochem, Parkville, Vic 3052, Australia

来源：

CANCER RESEARCH | 2009年 / 69卷 / 23期

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

UBIQUITIN LIGASE SIAH2; MURINE HOMOLOGS; GENE; P53; STABILITY; BINDING; IDENTIFICATION; TUMORIGENESIS; INHIBITION; HIPK2;

D O I：

10.1158/0008-5472.CAN-09-1676

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The Siah (seven in absentia homolog) family of RING-domain proteins are components of ubiquitin ligase complexes, targeting proteins for proteasomal degradation. Siah family members have been reported to function in Ras, estrogen, DNA-damage, and hypoxia response pathways. Although earlier reports implicated Siah proteins as tumor suppressors, recent studies in mouse models have shown that Siah inhibition impairs tumor growth and metastasis. Given their central role in oncogenic and angiogenic pathways, Siah proteins are attractive novel therapeutic targets in cancer. [Cancer Res 2009;69(23):8835-8]

引用

页码：8835 / 8838

页数：4

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