Clinical and Resistance Consequences of Misquantification of Plasma and Cerebrospinal Fluid Human Immunodeficiency Virus Type 1 (HIV-1) RNA in Samples from an HIV-1 Subtype G-Infected Patient

被引：13

作者：

Delaugerre, Constance ^{[1
]}

Denis, Blandine ^{[2
]}

Peytavin, Gilles ^{[3
]}

Palmer, Pierre ^{[1
]}

Mourez, Thomas ^{[1
]}

Le Goff, Jerome ^{[1
]}

Molina, Jean-Michel ^{[2
]}

Simon, Francois ^{[1
]}

机构：

[1] Hop St Louis, Dept Virol, APHP, F-75010 Paris, France

[2] Hop St Louis, Dept Infect Dis, APHP, F-75010 Paris, France

[3] Hop Bichat Claude Bernard, Dept Pharmacol, APHP, F-75877 Paris, France

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2009年 / 47卷 / 11期

关键词：

ABBOTT REALTIME; COBAS-TAQMAN; QUANTIFICATION; DISCREPANCIES; ASSAYS; LOAD;

D O I：

10.1128/JCM.00206-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Human immunodeficiency virus (HIV) load is the main marker used to monitor antiviral treatment efficacy and resistance. We report a case of underquantification of HIV type 1 (HIV-1) RNA in plasma and cerebrospinal fluid from an HIV-1 subtype G-infected woman, leading to delayed diagnosis of HIV encephalitis and to the emergence of drug resistance.

引用

页码：3763 / 3764

页数：2

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