Treatment of Resistant Obsessive-Compulsive Disorder With Ventral Capsular/Ventral Striatal Gamma Capsulotomy: A Pilot Prospective Study

被引：46

作者：

Lopes, Antonio Carlos ^{[1
,2
]}

Greenberg, Benjamin D. ^{[3
,4
]}

Noren, Georg ^{[3
,4
]}

Canteras, Miguel Montes ^{[5
]}

Busatto, Geraldo F. ^{[2
]}

de Mathis, Maria Eugenia ^{[2
]}

Taub, Anita ^{[2
]}

D'Alcante, Carina Chaubet ^{[2
]}

Hoexter, Marcelo Queiroz ^{[6
]}

Gouvea, Fernando Sauerbronn ^{[2
]}

Cecconi, Janaina Philippi ^{[2
]}

Gentil, Andre F. ^{[2
]}

Ferrao, Ygor Arzeno ^{[2
]}

Fuentes, Daniel ^{[2
]}

de Castro, Claudio Campi ^{[7
]}

Leite, Claudia C. ^{[8
]}

Salvajoli, Joao Victor ^{[5
]}

Duran, Fabio L. S. ^{[2
]}

Rasmussen, Steven ^{[3
,4
]}

Miguel, Euripedes Constantino ^{[2
]}

机构：

[1] Univ Sao Paulo, Obsess Compuls Spectrum Disorders Program PROTOC, Dept Psychiat, Sch Med, BR-01060970 Sao Paulo, Brazil

[2] Univ Sao Paulo, Sch Med, Inst Psychiat, BR-01060970 Sao Paulo, Brazil

[3] Brown Univ, Dept Psychiat & Human Behav, Warren Alpert Med Sch, Providence, RI 02912 USA

[4] Brown Univ, Dept Clin Neurosci Neurosurg, Warren Alpert Med Sch, Providence, RI 02912 USA

[5] Hosp Santa Paulo, Inst Neurol Radiosurg, Sao Paulo, Brazil

[6] Univ Fed Sao Paulo, Dept Psychiat, Sao Paulo, Brazil

[7] FMUSP, Inst Heart, INCOR, Sao Paulo, Brazil

[8] FMUSP, Dept Radiol, Sao Paulo, Brazil

来源：

JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES | 2009年 / 21卷 / 04期

基金：

巴西圣保罗研究基金会;

关键词：

STEREOTACTIC ANTERIOR CAPSULOTOMY; REFRACTORY ANXIETY DISORDERS; SCALE; RELIABILITY; DEPRESSION; STRATEGIES; INVENTORY; VALIDITY; BEHAVIOR; ISSUES;

D O I：

10.1176/appi.neuropsych.21.4.381

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A subgroup of obsessive-compulsive disorder (OCD) patients remains refractory to conventional treatments. For them, a new stereotactic radiosurgery has been recently developed: the ventral capsular/ventral striatal (VC/VS) gamma capsulotomy. The authors aim to report efficacy and adverse events of VC/VS gamma capsulotomy. Five refractory OCD patients were selected. The authors assessed OCD, anxiety and depressive symptoms, and side effects pre- and postoperatively. Three patients (60%) met response criteria 48 months after surgery. Adverse effects were episodic and transient. Ventral capsular/ventral striatal gamma capsulotomy holds therapeutic promise, with few adverse effects. (The Journal of Neuropsychiatry and Clinical Neurosciences 2009; 21:381-392)

引用

页码：381 / 392

页数：12