Nonsteroidal Anti-inflammatory Drug Use in Horses

被引：40

作者：

Knych, Heather K. ^{[1
]}

机构：

[1] Univ Calif Davis, Sch Vet Med, KL Maddy Equine Analyt Chem Lab, 620 West Hlth Sci Dr, Davis, CA 95616 USA

来源：

VETERINARY CLINICS OF NORTH AMERICA-EQUINE PRACTICE | 2017年 / 33卷 / 01期

关键词：

Nonsteroidal anti-inflammatory drugs; Horses; Analgesia; Anti-inflammatory; ASPIRIN-LIKE DRUGS; FLUNIXIN MEGLUMINE; CYCLOOXYGENASE-2; INHIBITORS; INDUCIBLE CYCLOOXYGENASE; PROSTAGLANDIN SYNTHESIS; MESSENGER-RNA; DORSAL COLON; PHENYLBUTAZONE; PHARMACOKINETICS; FIROCOXIB;

D O I：

10.1016/j.cveq.2016.11.001

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Nonsteroidal anti-inflammatory drugs (NSAIDs) are effective antiinflammatory and analgesic agents and are arguably the most commonly used class of drugs in equine medicine. This article provides a brief review of the mechanism of action, therapeutic uses, pharmacokinetics, and adverse effects associated with their use in horses. The use of COX -2 selective NSAIDs in veterinary medicine has increased over the past several years and special emphasis is given to the use of these drugs in horses. A brief discussion of the use of NSAIDs in performance horses is also included.

引用

页码：1 / +

页数：16

共 77 条

[31] Temporal effects of a COX-2-selective NSAID on bone ingrowth [J].

Goodman, SB ;

Ma, T ;

Mitsunaga, L ;

Miyanishi, K ;

Genovese, MC ;

Smith, RL .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2005, 72A (03) :279-287

[32] Prostaglandin synthase 2 [J].

Herschman, HR .

BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM, 1996, 1299 (01) :125-140

[33] ARACHIDONIC-ACID METABOLISM, PAIN AND HYPERALGESIA - THE MODE OF ACTION OF NON-STEROID MILD ANALGESICS [J].

HIGGS, GA .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1980, 10 :S233-S235

[34] Pharmacokinetics and pharmacodynamics of three formulations of firocoxib in healthy horses [J].

Holland, B. ;

Fogle, C. ;

Blikslager, A. T. ;

Curling, A. ;

Barlow, B. M. ;

Schirmer, J. ;

Davis, J. L. .

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 2015, 38 (03) :249-256

[35] Evaluation of the analgesic effects of phenylbutazone administered at a high or low dosage in horses with chronic lameness [J].

Hu, HH ;

MacAllister, CG ;

Payton, ME ;

Erkert, RS .

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 2005, 226 (03) :414-417

[36]

King J N, 1989, Equine Vet J Suppl, P38, DOI 10.1111/j.2042-3306.1989.tb05653.x

[37] Pharmacokinetics and effects on thromboxane B2 production following intravenous administration of flunixin meglumine to exercised thoroughbred horses [J].

Knych, H. K. ;

Arthur, R. M. ;

McKemie, D. S. ;

Chapman, N. .

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 2015, 38 (04) :313-320

[38] Detection and pharmacokinetics of three formulations of firocoxib following multiple administrations to horses [J].

Knych, H. K. ;

Stanley, S. D. ;

Arthur, R. M. ;

Mitchell, M. M. .

EQUINE VETERINARY JOURNAL, 2014, 46 (06) :734-738

[39] Pharmacokinetics of ketoprofen enantiomers following intravenous and oral administration to exercised Thoroughbred horses [J].

Knych, Heather K. ;

Arthur, Rick M. ;

Steinmetz, Stacy ;

McKemie, Dan S. .

VETERINARY JOURNAL, 2016, 207 :196-198

[40] Effects of diclofenac on periosteal callus maturation in osteotomy healing in an animal model [J].

Krischak, Gert D. ;

Augat, Peter ;

Sorg, Tobias ;

Blakytny, Robert ;

Kinzl, Lothar ;

Claes, Lutz ;

Beck, Alexander .

ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY, 2007, 127 (01) :3-9

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