Nonsteroidal Anti-inflammatory Drug Use in Horses

被引：38
作者：
Knych, Heather K. [1 ]
机构：
[1] Univ Calif Davis, Sch Vet Med, KL Maddy Equine Analyt Chem Lab, 620 West Hlth Sci Dr, Davis, CA 95616 USA
来源：
VETERINARY CLINICS OF NORTH AMERICA-EQUINE PRACTICE | 2017年 / 33卷 / 01期
关键词：
Nonsteroidal anti-inflammatory drugs; Horses; Analgesia; Anti-inflammatory; ASPIRIN-LIKE DRUGS; FLUNIXIN MEGLUMINE; CYCLOOXYGENASE-2; INHIBITORS; INDUCIBLE CYCLOOXYGENASE; PROSTAGLANDIN SYNTHESIS; MESSENGER-RNA; DORSAL COLON; PHENYLBUTAZONE; PHARMACOKINETICS; FIROCOXIB;
D O I：
10.1016/j.cveq.2016.11.001
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
Nonsteroidal anti-inflammatory drugs (NSAIDs) are effective antiinflammatory and analgesic agents and are arguably the most commonly used class of drugs in equine medicine. This article provides a brief review of the mechanism of action, therapeutic uses, pharmacokinetics, and adverse effects associated with their use in horses. The use of COX -2 selective NSAIDs in veterinary medicine has increased over the past several years and special emphasis is given to the use of these drugs in horses. A brief discussion of the use of NSAIDs in performance horses is also included.
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页码：1 / +
页数：16
相关论文
共 77 条
[1]   Cyclooxygenase-2 and its regulation in inflammation [J].
Bakhle, YS ;
Botting, RM .
MEDIATORS OF INFLAMMATION, 1996, 5 (05) :305-323
[2]   Non-steroidal anti-inflammatory drugs inhibit bone healing: A review [J].
Barry, S. .
VETERINARY AND COMPARATIVE ORTHOPAEDICS AND TRAUMATOLOGY, 2010, 23 (06) :385-392
[3]   Efficacy of cyclo-oxygenase inhibition by two commercially available firocoxib products in horses [J].
Barton, M. H. ;
Paske, E. ;
Norton, N. ;
King, D. ;
Giguere, S. ;
Budsberg, S. .
EQUINE VETERINARY JOURNAL, 2014, 46 (01) :72-75
[4]  
Baskett A, 1997, AM J VET RES, V58, P1291
[5]   Influence of diclofenac (group of nonsteroidal anti-inflammatory drugs) on fracture healing [J].
Beck, A ;
Krischak, G ;
Sorg, T ;
Augat, P ;
Farker, K ;
Merkel, U ;
Kinzl, L ;
Claes, L .
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY, 2003, 123 (07) :327-332
[6]   COX-1 and COX-2 inhibition in horse blood by phenylbutazone, flunixin, carprofen and meloxicam: An in vitro analysis [J].
Beretta, C ;
Garavaglia, G ;
Cavalli, M .
PHARMACOLOGICAL RESEARCH, 2005, 52 (04) :302-306
[7]   CHARACTERIZATION OF INDUCIBLE CYCLOOXYGENASE IN RAT-BRAIN [J].
BREDER, CD ;
DEWITT, D ;
KRAIG, RP .
JOURNAL OF COMPARATIVE NEUROLOGY, 1995, 355 (02) :296-315
[8]   Expression of inducible cyclooxygenase mRNA in the mouse brain after systemic administration of bacterial lipopolysaccharide [J].
Breder, CD ;
Saper, CB .
BRAIN RESEARCH, 1996, 713 (1-2) :64-69
[9]   In vitro effects of cyclooxygenase inhibitors in whole blood of horses, dogs, and cats [J].
Brideau, C ;
Van Staden, C ;
Chan, CC .
AMERICAN JOURNAL OF VETERINARY RESEARCH, 2001, 62 (11) :1755-1760
[10]   Interpreting the clinical significance of the differential inhibition of cyclooxygenase-1 and cyclooxygenase-2 [J].
Brooks, P ;
Emery, P ;
Evans, JF ;
Fenner, H ;
Hawkey, CJ ;
Patrono, C ;
Smolen, J ;
Breeveld, F ;
Day, R ;
Dougados, M ;
Ehrich, EW ;
Gijon-Baños, J ;
Kvien, TK ;
Van Rijswijk, MH ;
Warner, T ;
Zeidler, H .
RHEUMATOLOGY, 1999, 38 (08) :779-788
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