Preliminary analysis showed country-specific gut resistome based on 1267 feces samples

被引：21

作者：

Yang, Zhenyu ^{[1
]}

Guo, Zhirong ^{[2
]}

Qiu, Chuangzhao ^{[1
]}

Li, Yinhu ^{[1
]}

Feng, Xin ^{[1
]}

Liu, Yanhong ^{[4
]}

Zhang, Yanlin ^{[1
]}

Pang, Pengyu ^{[3
]}

Wang, Ping ^{[1
]}

Zhou, Qian ^{[1
]}

Han, Lijuan ^{[5
]}

Dai, Wenkui ^{[1
]}

机构：

[1] WeHealthGene, Shenzhen 518000, Peoples R China

[2] Capital Med Univ, Beijing Chest Hosp, Beijing TB & Thorac Tumor Res Inst, Beijing 100035, Peoples R China

[3] Baoji City Chinese Med Hosp, Dept Gastroenterol, Baoji 721001, Peoples R China

[4] BGI Shenzhen, Shenzhen 518083, Peoples R China

[5] City Univ Hong Kong, Dept Comp Sci, 83 Tat Chee Ave, Hong Kong, Hong Kong, Peoples R China

来源：

GENE | 2016年 / 581卷 / 02期

关键词：

Antibiotic; Gut microbiota; ARGs; ANTIBIOTIC-RESISTANCE GENES; CATALOG;

D O I：

10.1016/j.gene.2016.01.043

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Gut microbiota (GM) plays an important role in drug metabolism and absorption. Ever-increasing antibiotic use could result in high accumulation of antibiotic resistance genes (ARGs) in GM, which will reduce the recovery rate of many infectious diseases. The foci of this study is to unravel ARG distribution in GM of 1267 subjects from four countries in three continents, by annotation with ARDB (Antibiotic Resistance Genes Database) and ARG-ANNOT database. Analysis results showed that all three continents had similar ARG composition, but Chinese had the highest ARG relative abundance, followed by American and European. This is possibly attributed to delayed policies on antibiotic use in China, and restrict legislation in Europe. Delivery time and application scope are proportional to ARG enrichment in GM. Findings in this study indicate that ARG accumulation could be associated with government policies on antibiotic use, and corresponding delivery time and application scope, which will be a significant reference to control antibiotic abuse. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：178 / 182

页数：5

共 36 条

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