Copper as a Powerful Catalyst in the Direct Alkynylation of Azoles

被引：170
|
作者：
Besselievre, Francois [1 ]
Piguel, Sandrine [1 ]
机构：
[1] Ctr Univ Orsay, Inst Curie, UMR 176, CNRS, F-91405 Orsay, France
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 50期
关键词：
alkynes; alkynylation; C-H activation; copper; heterocycles; C-H BONDS; GACL3-CATALYZED ORTHO-ETHYNYLATION; DIRECT ARYLATION; HETEROAROMATIC-COMPOUNDS; ARYL BROMIDES; N-ARYLATION; PALLADIUM; HETEROARENES; HETEROCYCLES; OXAZOLES;
D O I：
10.1002/anie.200904776
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
[Chemical equation presented] Copper-bottomed catalysis! The direct alkynylation of azoles through a copper-based C - H bond activation, using alkynylbromides as the coupling partner, has been developed (see scheme). The method is very rapid, is functional-group tolerant, and provides a straightforward entry to diverse alkynyl heterocycles that is complementry to the Sonogashira reaction. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：9553 / 9556
页数：4
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