Copper as a Powerful Catalyst in the Direct Alkynylation of Azoles

被引：169

作者：

Besselievre, Francois ^{[1
]}

Piguel, Sandrine ^{[1
]}

机构：

[1] Ctr Univ Orsay, Inst Curie, UMR 176, CNRS, F-91405 Orsay, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 50期

关键词：

alkynes; alkynylation; C-H activation; copper; heterocycles; C-H BONDS; GACL3-CATALYZED ORTHO-ETHYNYLATION; DIRECT ARYLATION; HETEROAROMATIC-COMPOUNDS; ARYL BROMIDES; N-ARYLATION; PALLADIUM; HETEROARENES; HETEROCYCLES; OXAZOLES;

D O I：

10.1002/anie.200904776

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

[Chemical equation presented] Copper-bottomed catalysis! The direct alkynylation of azoles through a copper-based C - H bond activation, using alkynylbromides as the coupling partner, has been developed (see scheme). The method is very rapid, is functional-group tolerant, and provides a straightforward entry to diverse alkynyl heterocycles that is complementry to the Sonogashira reaction. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：9553 / 9556

页数：4

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