A structural model for the galactose oxidase active site which shows counteranion-dependent phenoxyl radical formation by disproportionation

被引：0

作者：

Shimazaki, Y

Huth, S

Odani, A

Yamauchi, O ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Sci, Dept Chem, Nagoya, Aichi 4648602, Japan

[2] Nagoya Univ, Res Ctr Mat Sci, Nagoya, Aichi 4648602, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2000年 / 39卷 / 09期

关键词：

copper; enzyme models; oxidoreductases; radical reactions;

D O I：

10.1002/(SICI)1521-3773(20000502)39:9<1666::AID-ANIE1666>3.0.CO;2-O

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel tetradentate ligand has been shown to react with Cu(OAc) 2 to form 1, which mimics the active-site structure of galactose oxidase. The reaction of the ligand with Cu(II) depends on the counterions available; the Cu(ClO 4) 2 ligand system gives a phenoxyl radical species and [Cu(CH 3CN) 4]ClO 4 by a disproportionation reaction (see scheme).

引用

页码：1666 / +

页数：5

共 40 条

[21] A three-coordinate copper(I)-phenoxide complex that models the reduced form of galactose oxidase
Jazdzewski, BA
Young, VG
Tolman, WB
[J]. CHEMICAL COMMUNICATIONS, 1998, (22) : 2521 - 2522
[22] MODELS FOR METHEMOCYANIN DERIVATIVES - STRUCTURAL AND SPECTROSCOPIC COMPARISONS OF RELATED AZIDO-COORDINATED (N3-) MONONUCLEAR AND DINUCLEAR COPPER(II) COMPLEXES
KARLIN, KD
COHEN, BI
HAYES, JC
FAROOQ, A
ZUBIETA, J
[J]. INORGANIC CHEMISTRY, 1987, 26 (01) : 147 - 153
[23] SYNTHESIS AND CHARACTERIZATION OF COPPER(II) COMPLEXES OF A TETRADENTATE N3O LIGAND - MONONUCLEAR ANALOGS FOR PHENOLATE-BRIDGED DINUCLEAR COMPLEXES
KARLIN, KD
COHEN, BI
[J]. INORGANICA CHIMICA ACTA-BIOINORGANIC CHEMISTRY, 1985, 107 (02): : L17 - L20
[24] SPECTROSCOPIC STUDIES OF THE ACTIVE-SITE OF GALACTOSE-OXIDASE
KNOWLES, PF
BROWN, RD
KOENIG, SH
WANG, S
SCOTT, RA
MCGUIRL, MA
BROWN, DE
DOOLEY, DM
[J]. INORGANIC CHEMISTRY, 1995, 34 (15) : 3895 - 3902
[25] RESONANCE RAMAN-SPECTROSCOPY OF GALACTOSE-OXIDASE - A NEW INTERPRETATION BASED ON MODEL-COMPOUND FREE-RADICAL SPECTRA
MCGLASHEN, ML
EADS, DD
SPIRO, TG
WHITTAKER, JW
[J]. JOURNAL OF PHYSICAL CHEMISTRY, 1995, 99 (14) : 4918 - 4922
[26] Müller J, 1998, ANGEW CHEM INT EDIT, V37, P616, DOI 10.1002/(SICI)1521-3773(19980316)37:5<616::AID-ANIE616>3.0.CO
[27] 2-4
[28] Muller J., 1998, ANGEW CHEM, V110, P637
[29] AN UNUSUAL AXIAL COORDINATION OF PHENOLATE OXYGEN TO COPPER(II) - CRYSTAL-STRUCTURE OF CHLORO(2-[BIS(2-PYRIDYL-METHYL)AMINOMETHYL]-4-NITROPHENOLATO)COPPER(II)
RAJENDRAN, U
VISWANATHAN, R
PALANIANDAVAR, M
LAKSHMINARAYANAN, M
[J]. JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1992, (24): : 3563 - 3564
[30] Structure and mechanism of galactose oxidase: Catalytic role of tyrosine 495
Reynolds, MP
Baron, AJ
Wilmot, CM
Vinecombe, E
Stevens, C
Phillips, SEV
Knowles, PF
McPherson, MJ
[J]. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 1997, 2 (03): : 327 - 335

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