A structural model for the galactose oxidase active site which shows counteranion-dependent phenoxyl radical formation by disproportionation

被引：0
作者：
Shimazaki, Y
Huth, S
Odani, A
Yamauchi, O [1 ]
机构：
[1] Nagoya Univ, Grad Sch Sci, Dept Chem, Nagoya, Aichi 4648602, Japan
[2] Nagoya Univ, Res Ctr Mat Sci, Nagoya, Aichi 4648602, Japan
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2000年 / 39卷 / 09期
关键词：
copper; enzyme models; oxidoreductases; radical reactions;
D O I：
10.1002/(SICI)1521-3773(20000502)39:9<1666::AID-ANIE1666>3.0.CO;2-O
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel tetradentate ligand has been shown to react with Cu(OAc) 2 to form 1, which mimics the active-site structure of galactose oxidase. The reaction of the ligand with Cu(II) depends on the counterions available; the Cu(ClO 4) 2 ligand system gives a phenoxyl radical species and [Cu(CH 3CN) 4]ClO 4 by a disproportionation reaction (see scheme).
引用
收藏
页码：1666 / +
页数：5
相关论文
共 40 条
  • [1] Heteroleptic tripodal complexes of copper(II) .2. Formation of axial phenolate-metal bonds in square-pyramidal complexes
    Adams, H
    Bailey, NA
    Campbell, IK
    Fenton, DE
    He, QY
    [J]. JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1996, (11): : 2233 - 2237
  • [2] TOWARDS A MODEL FOR GALACTOSE-OXIDASE - THE CRYSTAL-STRUCTURE OF (2-[BIS(2-PYRIDYLETHYL)AMINOMETHYL]PHENOLATO) COPPER(II) PERCHLORATE
    ADAMS, H
    BAILEY, NA
    FENTON, DE
    HE, QY
    OHBA, M
    OKAWA, H
    [J]. INORGANICA CHIMICA ACTA, 1994, 215 (1-2) : 1 - 3
  • [3] BARON AJ, 1994, J BIOL CHEM, V269, P25095
  • [4] Chaudhuri P, 1999, ANGEW CHEM INT EDIT, V38, P1095, DOI 10.1002/(SICI)1521-3773(19990419)38:8<1095::AID-ANIE1095>3.0.CO
  • [5] 2-I
  • [6] Aerobic oxidation of primary alcohols (including methanol) by copper(II)- and zinc(II)-phenoxyl radical catalysts
    Chaudhuri, P
    Hess, M
    Müller, J
    Hildenbrand, K
    Bill, E
    Weyhermüller, T
    Wieghardt, K
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (41) : 9599 - 9610
  • [7] Chaudhuri P, 1998, ANGEW CHEM INT EDIT, V37, P2217, DOI 10.1002/(SICI)1521-3773(19980904)37:16<2217::AID-ANIE2217>3.0.CO
  • [8] 2-D
  • [9] Chaudhuri P., 1998, ANGEW CHEM, V110, P2340
  • [10] Chaudhuri P., 1999, ANGEW CHEM, V111, P1165
1234