Synthesis of new sugar derivatives and evaluation of their antibacterial activities against Mycobacterium tuberculosis

被引：27

作者：

Horita, Yasuhiro ^{[1
]}

Takii, Takemasa ^{[1
]}

Chiba, Taku ^{[2
]}

Kuroishi, Ryuji ^{[1
]}

Maeda, Yasuhiro ^{[3
]}

Kurono, Yukihisa ^{[3
]}

Inagaki, Emi ^{[1
]}

Nishimura, Kenji ^{[1
]}

Yamamoto, Yoshifumi ^{[1
]}

Abe, Chiyoji ^{[4
]}

Mori, Masami ^{[2
]}

Onozaki, Kikuo ^{[1
]}

机构：

[1] Nagoya City Univ, Grad Sch Pharmaceut Sci, Dept Mol Hlth Sci, Nagoya, Aichi, Japan

[2] Kinjo Gakuin Univ, Coll Pharm, Nagoya, Aichi, Japan

[3] Nagoya City Univ, Grad Sch Pharmaceut Sci, Dept Hosp Pharm, Nagoya, Aichi, Japan

[4] Japan AntiTB Assoc, Res Inst TB, Tokyo, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 22期

关键词：

Carbohydrate; Tuberculosis; Antibacterial activity;

D O I：

10.1016/j.bmcl.2009.09.095

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of sugar derivatives (1-13) were synthesized and evaluated for antibacterial activity against Mycobacterium tuberculosis (MTB), especially multi-drug resistant (MDR) MTB, and the structure-activity relationships of these compounds were studied. The results showed that the compound OCT313 (2-acetamido-2deoxy-beta-D-glucopyranosyl N,N-dimethyldithiocarbamate) (4) exhibited significant in vitro bactericidal activity, and that the dithiocarbamate group at C-1 position of the glucopyranoside ring was requisite for the antibacterial activity. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：6313 / 6316

页数：4

共 6 条

[1] Mycobacterial persistence: adaptation to a changing environment [J].

Bentrup, KHZ ;

Russell, DG .

TRENDS IN MICROBIOLOGY, 2001, 9 (12) :597-605

[2] Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv [J].

Camus, JC ;

Pryor, MJ ;

Médigue, C ;

Cole, ST .

MICROBIOLOGY-SGM, 2002, 148 :2967-2973

[3] Synthesis of new sugar derivatives from Stachys sieboldi Miq and antibacterial evaluation against Mycobacterium tuberculosis, Mycobacterium avium, and Staphylococcus aureus [J].

Chiba, Taku ;

Takii, Takemasa ;

Nishimura, Kenji ;

Yamamoto, Yoshifumi ;

Morikawa, Hiroko ;

Abe, Chiyoji ;

Onozaki, Kikuo .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (09) :2487-2491

[4]

CONCHIE J, 1963, METHODS CARBOHYDRATE, V2, P332

[5] Recent advances in new structural classes of anti-tuberculosis agents [J].

Nayyar, A ;

Jain, R .

CURRENT MEDICINAL CHEMISTRY, 2005, 12 (16) :1873-1886

[6] The magic bullets and tuberculosis drug targets [J].

Ying, Z .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 2005, 45 :529-564

← 1 →