Normative Pentacam anterior and posterior corneal elevation measurements: effects of age, sex, axial length and white-to-white

Purpose To provide normal corneal elevation data for a large Caucasian population and to determine the impacts on these data of age, sex, axial length (AXL) and horizontal white-to-white (WW). Setting Centro Internacional de Oftalmologia Avanzada, Madrid, Spain. Design Retrospective, cross-sectional, observational. Methods In this retrospective, cross-sectional, observational study, anterior and posterior corneal elevations were measured in 789 right eyes of subjects with no ocular disease at the thinnest corneal location in relation to a fixed 8-mm best-fit sphere using the Pentacam, and AXL and WW were measured with the IOLMaster. A multiple linear regression model was used to assess the effects of age, sex, AXL and WW on the elevation data. Results Mean subject age was 50.5 +/- 15 years (range 17-93 years); 64% were women. Mean anterior and posterior corneal elevations were 1.99 +/- 1.75 mu m (- 7 to 10 mu m) and 7.70 +/- 5.7 mu m (- 6 to 28 mu m). Anterior corneal elevations were higher by 0.165 mu m and 0.033 mu m for every mm reduction in AXL and every year reduction in age, respectively. Sex and WW were not significant predictors of anterior elevations (R-2 = 7.7%). Posterior corneal elevation increased by 0.186 mu m/year of age, 0.707 mu m/mm reduction in WW and 0.819 mu m/mm reduction in AXL. This variable was also 0.866 mu m greater in men (R-2 = 34.4%). Conclusion Anterior corneal elevations decrease with age and are higher for shorter AXL but are not influenced by sex or WW. Posterior corneal elevations increase with age, decreasing AXL, decreasing WW and are higher in men.