A DNA chip off the aging block

被引：13

作者：

Cristofalo, VJ

机构：

[1] Lankenau Inst Med Res, Wynnewood, PA 19096 USA

[2] Thomas Jefferson Univ, Wynnewood, PA 19096 USA

来源：

NATURE MEDICINE | 2000年 / 6卷 / 05期

关键词：

D O I：

10.1038/74983

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Microarray analysis of gene expression differences between young and aging fibroblasts may provide insight into the complex biological process of aging. But do changes in cultured cells from a few individuals accurately reflect overall changes in aging people?

引用

页码：507 / 507

页数：1

共 4 条

[1] Relationship between donor age and the replicative lifespan of human cells in culture: A reevaluation
Cristofalo, VJ
Allen, RG
Pignolo, RJ
Martin, BG
Beck, JC
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (18) : 10614 - 10619
[2] SERIAL CULTIVATION OF HUMAN DIPLOID CELL STRAINS
HAYFLICK, L
MOORHEAD, PS
[J]. EXPERIMENTAL CELL RESEARCH, 1961, 25 (03) : 585 - +
[3] HAYFLICK L, 1965, EXP CELL RES, V37, P611
[4] LY, 2000, SCIENCE, V287, P2486

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