Some applications of the Grignard cross-coupling reaction in the industrial field

被引：65

作者：

Banno, T ^{[1
]}

Hayakawa, Y ^{[1
]}

Umeno, M ^{[1
]}

机构：

[1] Hokko Chem Ind Co Ltd, Fine Chem Res Labs, Atsugi, Kanagawa 2430023, Japan

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2002年 / 653卷 / 1-2期

关键词：

Grignard; cross-coupling reaction; chemical products;

D O I：

10.1016/S0022-328X(02)01165-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

We have been offering various fine chemical products used in a wide range of industrial fields by accumulated Grignard reaction technology. The prodcut, which we manufactured first in 1984 by the Grignard cross-coupling reaction, was p-chlorostyrene (PCST). PCST is useful as a raw material for functional polymers and synthetic reagents. For the industrialization of PCST, we used the nickel-phophine catalyzed cross-coupling reaction reported by Kumada and Tamao in 1972. We have been manufacturing various kinds of compounds using cross-coupling reaction after development of PCST. In this paper, we describe four types of the Grignard cross-coupling reactions currently carried out in our company. In addition, we show the plant performing the Grignard cross-coupling reaction, and describe the manufacturing process. (C) 2002 Published by Elsevier Science B.V.

引用

页码：288 / 291

页数：4

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