Sequential Time-Kill, a Simple Experimental Trick To Discriminate between Pharmacokinetics/Pharmacodynamics Models with Distinct Heterogeneous Subpopulations versus Homogenous Population with Adaptive Resistance

被引：5

作者：

Chauzy, A. ^{[1
]}

Ih, H. ^{[1
,3
]}

Jacobs, M. ^{[1
,4
]}

Marchand, S. ^{[1
,2
]}

Gregoire, N. ^{[1
,2
]}

Couet, W. ^{[1
,2
]}

Buyck, J. M. ^{[1
]}

机构：

[1] Univ Poitiers, UFR Med Pharm, INSERM U1070 Pharmacol Antiinfect, Poitiers, France

[2] CHU Poitiers, Lab Toxicol Pharmacocinet, Poitiers, France

[3] Univ Tanjungpura, Fac Med, Pharm Dept, Pontianak, Indonesia

[4] Technol Servier, Vignat Orleans, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2020年 / 64卷 / 08期

关键词：

Klebsiella pneumoniae; PK/PD model; antibiotic resistance; pharmacodynamics; polymyxin B; sequential time-kill; PHARMACOKINETIC-PHARMACODYNAMIC MODEL;

D O I：

10.1128/AAC.00788-20

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Experiments were conducted with polymyxin B and two Klebsiella pneumonia isogenic strains (the wild type, KP_WT, and its transconjugant carrying the mobile colistin resistance gene, KP_MCR-1) to demonstrate that conducting two consecutive time-kill experiments (sequential TK) represents a simple approach to discriminate between pharmacokinetics/pharmacodynamics models with two heterogeneous subpopulations or adaptive resistance.

引用

页数：5

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