Rhodium(III)-Catalyzed Oxidative C-H/C-H Cross-Coupling of Heteroarenes and Masked Benzylamines

被引：30

作者：

Hu, Jundie ^{[1
]}

Li, Guobao ^{[1
]}

Yuan, Chunchen ^{[1
]}

Huang, Zhi-Bin ^{[1
]}

Shi, Da-Qing ^{[1
]}

Zhao, Yingsheng ^{[1
]}

机构：

[1] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 23期

基金：

中国国家自然科学基金;

关键词：

CARBOXYLIC-ACIDS; DEHYDROGENATIVE HETEROARYLATION; SOLAR-CELLS; THIOPHENES; 1,3-AZOLES; ACCESS; DERIVATIVES; SEMICONDUCTORS; HETEROCYCLES; PYRIDINES;

D O I：

10.1021/acs.orglett.6b02773

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first example of oxidative C-H/C-H cross coupling of oxalyl amide-protected benzylamines and various heteroarenes in the presence of a rhodium(III) catalyst has been developed. The route provides a means of synthesizing ortho-heteroarylated benzylamines. The methodology presents broad substrate scope, great functional group tolerance, and good to excellent yields in the synthesis of substituted benzylamines. The study also reveals that the thienoisoquinoline derivatives can be accessed through the intramolecular amination of thiophenyl-substituted benzylamines with palladium(II).

引用

收藏

页码：5998 / 6001

页数：4

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