Changes in Body Composition in Patients with Chronic Obstructive Pulmonary Disease: Do They Influence Patient-Related Outcomes?

被引：52

作者：

Rutten, Erica P. A. ^{[1
]}

Calverley, Peter M. A. ^{[2
]}

Casaburi, Richard ^{[3
]}

Agusti, Alvar ^{[4
,5
]}

Bakke, Per ^{[6
]}

Celli, Bartolome ^{[7
,8
]}

Coxson, Harvey O. ^{[9
]}

Crim, Courtney ^{[10
]}

Lomas, David A. ^{[11
]}

MacNee, William ^{[12
]}

Miller, Bruce E. ^{[13
]}

Rennard, Stephan I. ^{[14
]}

Scanlon, Paul D. ^{[15
]}

Silverman, Edwin K. ^{[7
,8
]}

Tal-Singer, Ruth ^{[13
]}

Vestbo, Jorgen ^{[16
,17
,18
]}

Watkins, Michael L. ^{[10
]}

Wouters, Emiel F. M. ^{[19
]}

机构：

[1] Ctr Expertise Chron Organ Failure Ciro, Horn, Netherlands

[2] Univ Liverpool, Liverpool L69 3BX, Merseyside, England

[3] Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Rehabil Clin Trail Ctr, Torrance, CA 90509 USA

[4] Univ Barcelona, Hosp Clin, Thorax Inst, Inst Invest Biomed August Pi & Sunyer, Barcelona, Spain

[5] CIBER Enfermedades Resp, Palma De Mallorca, Spain

[6] Univ Bergen, Inst Med, Bergen, Norway

[7] Brigham & Womens Hosp, Boston, MA 02115 USA

[8] Harvard Univ, Sch Med, Boston, MA USA

[9] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada

[10] GlaxoSmithKline, Durham, NC USA

[11] Univ Cambridge, Cambridge Inst Med Res, Cambridge, England

[12] Univ Edinburgh, Edinburgh, Midlothian, Scotland

[13] GlaxoSmithKline, King Of Prussia, PA USA

[14] Univ Nebreska Med Ctr, Omaha, NE USA

[15] Mayo Clin, Rochester, MN USA

[16] Univ Copenhagen, Hvidovre Hosp, Resp Sect, DK-2650 Hvidovre, Denmark

[17] Univ Copenhagen, Copenhagen, Denmark

[18] Univ Manchester, Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England

[19] Univ Maastricht, Maastricht, Netherlands

来源：

ANNALS OF NUTRITION AND METABOLISM | 2013年 / 63卷 / 03期

关键词：

Body composition; Chronic obstructive pulmonary disease; Fat free mass index; Fat mass index; Health status; Mortality; QUALITY-OF-LIFE; FAT-FREE MASS; PROGNOSTIC VALUE; NUTRITIONAL DEPLETION; HEALTH-STATUS; COPD; MORTALITY; MORBIDITY; FAILURE; DECLINE;

D O I：

10.1159/000353211

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims: The follow-up of the ECLIPSE study, a prospective longitudinal study to identify and define parameters that predict disease progression over 3 years in chronic obstructive pulmonary disease (COPD), allows the examination of the effect of body composition changes on COPD-related outcomes. Methods: Body composition and health status were established in 2,115 COPD patients, 327 smoking and 239 nonsmoking controls at baseline and 3 years, while mortality was recorded in year 2 and 3 in the COPD patients. Associations between fat free mass index (FFMI) and fat mass index (FMI) changes to deterioration in health status and mortality were determined. Results: Change in FFMI and FMI over 3 years was small and comparable between the groups. Underweight and obese patients had the worst health status. Worsening health status was associated with FFMI decrease in underweight patients and FMI increase in overweight/obese patients. While overweight patients had the lowest mortality, FFMI or FMI decrease was associated with a higher mortality. Conclusion: Changes in body composition over 3 years were small and comparable in COPD patients and control subjects. Nevertheless, muscle mass decline in underweight and fat mass increase in overweight/obese patients is associated with worsening health status. Overweight is associated with decreased mortality, but muscle mass and fat mass decline are detrimental for mortality. (C) 2013 S. Karger AG, Basel

引用

页码：239 / 247

页数：9

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