Journey of Mesenchymal Stem Cells for Homing: Strategies to Enhance Efficacy and Safety of Stem Cell Therapy

被引：190
作者：
Kang, Sung Keun [1 ]
Shin, Il Seob [1 ]
Ko, Myung Soon [1 ]
Jo, Jung Youn [1 ]
Ra, Jeong Chan [1 ]
机构：
[1] RNL BIO, Stem Cell Res Ctr, Seoul 153768, South Korea
来源：
STEM CELLS INTERNATIONAL | 2012年 / 2012卷
关键词：
HUMAN ADIPOSE-TISSUE; MARROW STROMAL CELLS; ACUTE MYOCARDIAL-INFARCTION; BONE-MARROW; IN-VIVO; IFATS COLLECTION; OSTEOGENIC DIFFERENTIATION; CEREBRAL-ISCHEMIA; PROGENITOR CELLS; PROMOTING MIGRATION;
D O I：
10.1155/2012/342968
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Human mesenchymal stem cells (MSCs) communicate with other cells in the human body and appear to "home" to areas of injury in response to signals of cellular damage, known as homing signals. This review of the state of current research on homing of MSCs suggests that favorable cellular conditions and the in vivo environment facilitate and are required for the migration of MSCs to the site of insult or injury in vivo. We review the current understanding of MSC migration and discuss strategies for enhancing both the environmental and cellular conditions that give rise to effective homing of MSCs. This may allow MSCs to quickly find and migrate to injured tissues, where they may best exert clinical benefits resulting from improved homing and the presence of increased numbers of MSCs.
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页数：11
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