Suppression of KCNQ/M Potassium Channel in Dorsal Root Ganglia Neurons Contributes to the Development of Osteoarthritic Pain

被引：13

作者：

Zhang, Fan ^{[1
]}

Liu, Yani ^{[2
]}

Zhang, Dandan ^{[1
]}

Fan, Xizhenzi ^{[1
]}

Shao, Decheng ^{[3
]}

Li, Han ^{[3
]}

机构：

[1] Hebei Med Univ, Dept Biochem & Mol Biol, Shijiazhuang, Hebei, Peoples R China

[2] Qingdao Univ, Sch Pharm, Dept Pharmacol, Qingdao, Shandong, Peoples R China

[3] Hebei Med Univ, Hosp 3, Dept Orthopaed Surg, Biomech Key Lab Hebei Prov,Inst Biomech Sci, Shijiazhuang, Hebei, Peoples R China

来源：

PHARMACOLOGY | 2019年 / 103卷 / 5-6期

基金：

中国国家自然科学基金;

关键词：

KCNQ/M channels; Osteoarthritic pain; Dorsal root ganglia; Modulators; RAT MODEL; RETIGABINE; OPENER; PERSISTENT;

D O I：

10.1159/000496422

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Osteoarthritic pain has a strong impact on patients' quality of life. Understanding the pathogenic mechanisms underlying osteoarthritic pain will likely lead to the development of more effective treatments. In the present study of osteoarthritic model rats, we observed a reduction of M-current density and a remarkable decrease in the levels of KCNQ2 and KCNQ3 proteins and mRNAs in dorsal root ganglia (DRG) neurons, which were associated with hyperalgesic behaviors. The activation of KCNQ/M channels with flupirtine significantly increased the mechanical threshold and prolonged the withdrawal latency of osteoarthritic model rats at 3-14 days after model induction, and all effects of flupirtine were blocked by KCNQ/M-channel antagonist, XE-991. Together, these results indicate that suppression of KCNQ/M channels in primary DRG neurons plays a crucial role in the development of osteoarthritic pain. (c) 2019 S. Karger AG, Basel

引用

页码：257 / 262

页数：6

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