Principles of ubiquitin and SUMO modifications in DNA repair

被引：446

作者：

Bergink, Steven ^{[1
]}

Jentsch, Stefan ^{[1
]}

机构：

[1] Max Planck Inst Biochem, Dept Mol Cell Biol, D-82152 Martinsried, Germany

来源：

NATURE | 2009年 / 458卷 / 7237期

关键词：

BINDING PROTEINS; DAMAGE; COMPLEX; PCNA; LIGASE; UBIQUITYLATION; RECOMBINATION; PROTEOLYSIS; BRCA1; GLYCOSYLASE;

D O I：

10.1038/nature07963

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

With the discovery in the late 1980s that the DNA-repair gene RAD6 encodes a ubiquitin-conjugating enzyme, it became clear that protein modification by ubiquitin conjugation has a much broader significance than had previously been assumed. Now, two decades later, ubiquitin and its cousin SUMO are implicated in a range of human diseases, including breast cancer and Fanconi anaemia, giving fresh momentum to studies focused on the relationships between ubiquitin, SUMO and DNA-repair pathways.

引用

页码：461 / 467

页数：7

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