Improvement of Severe COVID-19 in an Elderly Man by Sequential Use of Antiviral Drugs

被引：3

作者：

Yatomi, Masakiyo ^{[1
]}

Takazawa, Tomonori ^{[2
]}

Yanagisawa, Kunio ^{[3
]}

Kanamoto, Masafumi ^{[2
]}

Matsui, Yusuke ^{[2
]}

Tsukagoshi, Hiroyuki ^{[4
]}

Saruki, Nobuhiro ^{[4
]}

Saito, Shigeru ^{[2
]}

Tokue, Yutaka ^{[3
]}

Maeno, Toshitaka ^{[1
]}

机构：

[1] Gunma Univ Hosp, Integrat Ctr Internal Med, Dept Allergy & Resp Med, 3-39-15 Showa Machi, Maebashi, Gunma 3718511, Japan

[2] Gunma Univ Hosp, Intens Care Unit, 3-39-15 Showa Machi, Maebashi, Gunma 3718511, Japan

[3] Gunma Univ Hosp, Infect Control & Prevent Ctr, 3-39-15 Showa Machi, Maebashi, Gunma 3718511, Japan

[4] Gunma Prefectural Inst Publ Hlth & Environm Sci, 378 Kamioki Machi, Maebashi, Gunma 3710052, Japan

来源：

CASE REPORTS IN INFECTIOUS DISEASES | 2020年 / 2020卷

关键词：

CORONAVIRUS;

D O I：

10.1155/2020/8814249

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Although a variety of existing drugs are being tested for patients with coronavirus disease 2019 (COVID-19), no efficacious treatment has been found so far, particularly for severe cases. We report successful recovery in an elderly patient with severe pneumonia requiring mechanical ventilation and extracorporeal membrane oxygenation (ECMO). Despite administration of multiple antiviral drugs, including lopinavir/ritonavir, chloroquine, and favipiravir, the patient's condition did not improve. However, after administration of another antiviral drug, remdesivir, we were able to terminate invasive interventions, including ECMO, and subsequently obtained negative polymerase chain reaction results. Although further validation is needed, remdesivir might be effective in treating COVID-19.

引用

页数：4

共 13 条

[11] Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro
Wang, Manli
Cao, Ruiyuan
Zhang, Leike
Yang, Xinglou
Liu, Jia
Xu, Mingyue
Shi, Zhengli
Hu, Zhihong
Zhong, Wu
Xiao, Gengfu
[J]. CELL RESEARCH, 2020, 30 (03) : 269 - 271
[12] Yasukawa M., 2017, DEV EFFECTIVE TREATM
[13] Potential interventions for novel coronavirus in China: A systematic review
Zhang, Lei
Liu, Yunhui
[J]. JOURNAL OF MEDICAL VIROLOGY, 2020, 92 (05) : 479 - 490

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