Can Red cell distribution width screen for metabolic abnormality in women with Polycystic Ovarian Syndrome?

被引:0
作者
Nori, Wassan [1 ]
Harmoosh, Shaima K. [2 ]
Al-Badri, Hadeel J. Abd [1 ]
机构
[1] Mustansiriyah Univ, Coll Med, Dept Obstet & Gynecol, Baghdad, Iraq
[2] Al Yarmouk Teaching Hosp, Infertil Clin, Baghdad, Iraq
关键词
Red distribution width; PCOS; metabolic syndrome; insulin resistance; MEAN PLATELET VOLUME; ASSOCIATION; PREVALENCE; RESISTANCE; CRITERIA; INSULIN; EXCESS; RATIO;
D O I
暂无
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Polycystic ovarian syndrome (PCOS) is a prevalent endocrinopathy in reproductive-age females, ac-credited to a chronic low-grade inflammatory reaction. Red distribution width (RDW), a parameter of complete blood count, was tested as an inflammatory marker ; higher RDW was linked to metabolic syndrome. We aimed to examine RDW in distinguishing PCOS-related metabolic and hormonal abnormalities. Methods : A case-control study recruited 128 women, divided into PCOS cases (64 / 128) and controls (64 / 128) according to Rotterdam criteria. Body mass index (BMI), estimated complete blood count parameters, hormonal markers (serum follicle -stimulating hormone (FSH), luteinizing hormone, and serum testosterone), and metabolic markers (HOMA-IR, serum high and low-density lipoprotein) were measured. Results showed that RDW was significantly higher in PCOS. HOMA-IR, LDL, testosterone, and LH / FSH were higher in PCOS and strongly correlated with RDW with positive correlations. HDL was elevated and correlated negatively with RDW in PCOS. ROC calculated (13.55) as RDW cut-off value for insulin-resistant with an AUC of 0.95, P < 0.001. In conclusion, a strong and remarkable correlation of RDW with metabolic abnormalities in PCOS cases with 100% sensitivity and specificity, in addition to being quick and inexpensive, makes it a reliable marker for screening for insulin resistance.
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页码:191 / 195
页数:5
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