Identification of two atypical PML-RARα transcripts in two patients with acute promyelocytic leukemia

被引：18

作者：

Barragán, E

Bolufer, P

Martín, G

Cervera, J

Moreno, I

Capote, FJ

Rosique, P

Sanz, MA

机构：

[1] Hosp Univ La Fe, Ctr Maternal, Dept Clin Pathol, Mol Biol Lab, Valencia 46009, Spain

[2] Hosp Univ La Fe, Ctr Maternal, Dept Hemathol, Valencia 46009, Spain

[3] Hosp Univ Puerta Mar Cadiz, Dept Hemathol, Cadiz 11009, Spain

[4] Hosp Univ Virgen Arrixaca, Dept Hemathol, Murcia 30120, Spain

来源：

LEUKEMIA RESEARCH | 2002年 / 26卷 / 05期

关键词：

acute promyclocytic leukemia; PML-RAR alpha; RAR alpha-PML;

D O I：

10.1016/S0145-2126(01)00158-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We identified two patients with atypical PML-RARalpha rearrangements, 53 and 13 base pairs longer than the typical bcrl transcript. Sequence analysis revealed a new PML breakpoint at the end of exon 7a in patient 1, and a PML exon 6 breakpoint in patient 2, with an insertion of 35 nucleotides of RARalpha intron 2. Patient I did not express RARalpha,-PML and patient 2 showed the RARalpha-PML transcript, which corresponded to the typical bcrl. These results emphasize on the relevance of the correct identification of atypical PML-RARalpha rearrangements because of the potential implications in leukemogenesis, in the response to treatment, and for the correct monitoring of minimal residual disease. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：439 / 442

页数：4