Synthetic biodegradable functional polymers for tissue engineering: a brief review

被引：424

作者：

Guo BaoLin ^{[1
]}

Ma, Peter X. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Ctr Biomed Engn & Regenerat Med, Xian 710049, Peoples R China

[2] Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Dept Biol & Mat Sci, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Macromol Sci & Engn Ctr, Ann Arbor, MI 48109 USA

[5] Univ Michigan, Dept Mat Sci & Engn, Ann Arbor, MI 48109 USA

来源：

SCIENCE CHINA-CHEMISTRY | 2014年 / 57卷 / 04期

基金：

中国国家自然科学基金; 美国国家卫生研究院; 美国国家科学基金会;

关键词：

synthetic biodegradable polymers; functional polymers; scaffolds; tissue engineering; POLY(LACTIC-CO-GLYCOLIC ACID) MICROSPHERES; ELECTRICALLY CONDUCTING POLYMERS; RING-OPENING POLYMERIZATION; NANOFIBROUS SCAFFOLDS; ALIPHATIC POLYESTERS; COMPOSITE SCAFFOLDS; ANILINE OLIGOMERS; CELL-ADHESION; HYDROGELS; DRUG;

D O I：

10.1007/s11426-014-5086-y

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Scaffolds play a crucial role in tissue engineering. Biodegradable polymers with great processing flexibility are the predominant scaffolding materials. Synthetic biodegradable polymers with well-defined structure and without immunological concerns associated with naturally derived polymers are widely used in tissue engineering. The synthetic biodegradable polymers that are widely used in tissue engineering, including polyesters, polyanhydrides, polyphosphazenes, polyurethane, and poly (glycerol sebacate) are summarized in this article. New developments in conducting polymers, photoresponsive polymers, amino-acid-based polymers, enzymatically degradable polymers, and peptide-activated polymers are also discussed. In addition to chemical functionalization, the scaffold designs that mimic the nano and micro features of the extracellular matrix (ECM) are presented as well, and composite and nanocomposite scaffolds are also reviewed.

引用

页码：490 / 500

页数：11

共 109 条

[1] Controlled Thermoresponsive Hydrogels by Stereocomplexed PLA-PEG-PLA Prepared via Hybrid Micelles of Pre-Mixed Copolymers with Different PEG Lengths [J].