Mechanisms of spindle positioning: cortical force generators in the limelight

被引：115
作者：
Kotak, Sachin [1 ]
Goenczy, Pierre [1 ]
机构：
[1] Swiss Fed Inst Technol EPFL, Sch Life Sci, Swiss Inst Expt Canc Res ISREC, CH-1005 Lausanne, Switzerland
来源：
CURRENT OPINION IN CELL BIOLOGY | 2013年 / 25卷 / 06期
基金：
瑞士国家科学基金会;
关键词：
ASYMMETRIC CELL-DIVISION; CAENORHABDITIS-ELEGANS EMBRYO; MITOTIC SPINDLE; C.-ELEGANS; G-ALPHA; EARLY EMBRYOGENESIS; CYTOPLASMIC DYNEIN; ADHERENT CELLS; ORIENTATION; PROTEINS;
D O I：
10.1016/j.ceb.2013.07.008
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Correct positioning of the spindle governs placement of the cytokinesis furrow and thus plays a crucial role in the partitioning of fate determinants and the disposition of daughter cells in a tissue. Converging evidence indicates that spindle positioning is often dictated by interactions between the plus-end of astral microtubules that emanate from the spindle poles and an evolutionary conserved cortical machinery that serves to pull on them. At the heart of this machinery lies a ternary complex (LIN-5/GPR-1/2/G alpha in Caenorhabditis elegans and NuMA/LGN/G alpha i in Homo sapiens) that promotes the presence of the motor protein dynein at the cell cortex. In this review, we discuss how the above components contribute to spindle positioning and how the underlying mechanisms are precisely regulated to ensure the proper execution of this crucial process in metazoan organisms
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收藏
页码：741 / 748
页数：8
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