Aegicerin, the first oleanane triterpene with wide-ranging antimycobacterial activity, isolated from Clavija procera

被引：46
作者：
Rojas, Rosario
Caviedes, Luz
Aponte, Jose C.
Vaisberg, Abraham J.
Lewis, Walter H.
Lamas, Gerardo
Sarasara, Cesar
Gilman, Robert H.
Hammond, Gerald B. [1 ]
机构：
[1] Univ Louisville, Dept Chem, Louisville, KY 40292 USA
[2] Univ Peruana Cayetano Heredia, Dept Ciencias Farmaceut, Lima, Peru
[3] Univ Peruana Cayetano Heredia, Dept Microbiol, Lima, Peru
[4] Univ Peruana Cayetano Heredia, Lab Invest & Desarrollo, Lima, Peru
[5] Washington Univ, Dept Biol, St Louis, MO 63130 USA
[6] Univ Nacl Mayor San Marcos, Dept Entomol, Museum Nat Hist, Lima 14, Peru
[7] CONAP, Lima, Peru
[8] Johns Hopkins Univ, Sch Publ Hlth, Dept Int Hlth, Baltimore, MD 21205 USA
来源：
JOURNAL OF NATURAL PRODUCTS | 2006年 / 69卷 / 05期
关键词：
D O I：
10.1021/np050554l
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
An ethanol extract of the Peruvian plant Clavija procera, a member of the rare Theophrastaceae family, was fractionated using a colorimetric bioassay-guided protocol against Mycobacterium tuberculosis (MTB), yielding the oleanane triterpenoid aegicerin (1) as the active constituent. Its MIC values ranged between 1.6 and 3.12 mu g/mL against 37 different sensitive and resistant MTB strains (1 H37Rv, 21 susceptible clinical isolates, 2 INH-resistant clinical isolates, and 13 MDR clinical isolates).
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页码：845 / 846
页数：2
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