The role of innate lymphoid cells 2 in the allergic inflammation

被引:0
作者
Gawrysiak, Mateusz [1 ]
Szewczyk, Robert [1 ]
Kowalski, Marek L. [1 ]
Chalubinski, Maciej [1 ]
机构
[1] Uniwersytet Med Lodzi, Klin Immunol & Alergii, Ul Pomorska 251, PL-92213 Lodz, Poland
来源
ALERGIA ASTMA IMMUNOLOGIA | 2020年 / 25卷 / 02期
关键词
ILC2; allergic inflammation; allergy; T2-type immune response; TYPE-2; IMMUNITY; AIRWAY; ASTHMA;
D O I
暂无
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
ILC2s are a very important element of the innate immunity. Physiologically, the take part in the defense of the host against helmint infections. In pathological conditions, they become a link in the series of immune events of allergic inflammatory response. ILC2s activated by tissue-derived alarmins, such as IL-33, IL-25 and TSLP, release IL-4 and IL-5 affecting immune effectory cells, thus enhancing T2-dependent immune responses.
引用
收藏
页码:64 / 69
页数:6
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