Chrysanolide A, an unprecedented sesquiterpenoid trimer from the flowers of Chrysanthemum indicum L

被引:29
作者
Gu, Qiong [1 ,2 ]
Chen, Yaoyao [3 ]
Cui, Hui [1 ,2 ]
Huang, Dane [1 ,2 ]
Zhou, Jingwei [1 ,2 ]
Wu, Taizong [1 ,2 ]
Chen, Yiping [3 ]
Shi, Lina [1 ,2 ]
Xu, Jun [1 ,2 ]
机构
[1] Sun Yat Sen Univ, Res Ctr Drug Discovery, Guangzhou 510006, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Inst Human Virol, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China
[3] Guangxi Univ Chinese Med, Guangxi 530001, Peoples R China
基金
中国国家自然科学基金;
关键词
ELECTRONIC CIRCULAR-DICHROISM; RHUS-CHINENSIS; CONSTITUENTS; LACTONES; EXTRACTS; CANCER;
D O I
10.1039/c3ra23172k
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Chrysanolide A, a novel guaianolide-type sesquiterpenoid trimer (3), along with its biogenetically related monomer (Chrysanolide B, 1) and dimer (Chrysanolide C, 2), were simultaneously isolated from Chrysanthemum indicum L flowers. Their structures and absolute configurations were elucidated via spectroscopic and computational methods. All isolated compounds were evaluated for their anti-HBV activities.
引用
收藏
页码:10168 / 10172
页数:5
相关论文
共 22 条
[1]   Anti-tumor promoting effects of multiflorane-type triterpenoids and cytotoxic activity of karounidiol against human cancer cell lines [J].
Akihisa, T ;
Tokuda, H ;
Ichiishi, E ;
Mukainaka, T ;
Toriumi, M ;
Ukiya, M ;
Yasukawa, K ;
Nishino, H .
CANCER LETTERS, 2001, 173 (01) :9-14
[2]  
BRAULIO MF, 2009, NAT PROD REP, V26, P1125
[3]  
Chen Z. N., 1987, ACTA PHARM SINICA, V22
[4]   Anti-inflammatory and immunomodulatory activities of the extracts from the inflorescence of Chrysanthemum indicum Linne [J].
Cheng, WM ;
Li, J ;
You, TP ;
Hu, CM .
JOURNAL OF ETHNOPHARMACOLOGY, 2005, 101 (1-3) :334-337
[5]   Systematic investigation of modern quantum chemical methods to predict electronic circular dichroism spectra [J].
Diedrich, C ;
Grimme, S .
JOURNAL OF PHYSICAL CHEMISTRY A, 2003, 107 (14) :2524-2539
[6]   Theoretical Calculation of Electronic Circular Dichroism of a Hexahydroxydiphenoyl-Containing Flavanone Glycoside [J].
Ding, Yuanqing ;
Li, Xing-Cong ;
Ferreira, Daneel .
JOURNAL OF NATURAL PRODUCTS, 2009, 72 (03) :327-335
[7]   Swerilactones E-G, three unusual lactones from Swertia mileensis [J].
Geng, Chang-An ;
Zhang, Xue-Mei ;
Ma, Yun-Bao ;
Jiang, Zhi-Yong ;
Luo, Jie ;
Zhou, Jun ;
Wang, Hong-Ling ;
Chen, Ji-Jun .
TETRAHEDRON LETTERS, 2010, 51 (18) :2483-2485
[8]   Swerilactones A and B, Anti-HBV New Lactones from a Tradtional Chinese Herb: Swertia mileensis as a Treatment for Viral Hepatitis [J].
Geng, Chang-An ;
Jiang, Zhi-Yong ;
Ma, Yun-Bao ;
Luo, Jie ;
Zhang, Xue-Mei ;
Wang, Hong-Ling ;
Shen, Yong ;
Zuo, Ai-Xue ;
Zhou, Jun ;
Chen, Ji-Jun .
ORGANIC LETTERS, 2009, 11 (18) :4120-4123
[9]   A new benzofuranone and anti-HIV constituents from the stems of Rhus chinensis [J].
Gu, Qiong ;
Wang, Rui-Rui ;
Zhang, Xue-Mei ;
Wang, Yun-Hua ;
Zheng, Yong-Tang ;
Zhou, Jun ;
Chen, Ji-Jun .
PLANTA MEDICA, 2007, 73 (03) :279-282
[10]   Inhibition of xanthine oxidase by some Chinese medicinal plants used to treat gout [J].
Kong, LD ;
Cai, Y ;
Huang, WW ;
Cheng, CHK ;
Tan, RX .
JOURNAL OF ETHNOPHARMACOLOGY, 2000, 73 (1-2) :199-207