Quinolones in the Search for New Anticancer Agents

被引：35

作者：

Batalha, Pedro Netto ^{[1
]}

Bastos Vieira de Souza, Maria Cecilia ^{[1
]}

Pena-Cabrera, Eduardo ^{[2
]}

Cruz Cruz, David ^{[2
]}

Santos Boechat, Fernanda da Costa ^{[1
]}

机构：

[1] Univ Fed Fluminense, Inst Quim, Dept Quim Organ, Outeiro Sao Joao Batista S-N, BR-24020150 Niteroi, RJ, Brazil

[2] Univ Guanajuato, Dept Quim, Guanajuato, Mexico

来源：

CURRENT PHARMACEUTICAL DESIGN | 2016年 / 22卷 / 39期

关键词：

Quinolones; cancer; topoisomerase; complexes; anticancer activity; photochemistry; natural products; VITRO PHARMACOLOGICAL EVALUATION; PHOTOCHEMICAL-SYNTHESIS; BIOLOGICAL EVALUATION; ANTITUMOR EVALUATION; KINASE INHIBITORS; CRYSTAL-STRUCTURE; TOPOISOMERASE-I; DERIVATIVES; DESIGN; COMPLEXES;

D O I：

10.2174/1381612822666160715115025

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Quinolones have a large bio-dynamicity. Although they are well known as antibacterials, another important activity has been investigated - quinolones are able to inhibit cancer cell proliferation. In view of the great versatility associated with the synthesis of quinolones, many researchers have spent time and resources on the development of new structurally diversified quinolone derivatives with the purpose of finding new possibilities for cancer treatment. In this review some of the most recent advances in the search for new quinolone anticancer agents are highlighted, with focus on naturally occurring substances, bioactive metal complexes, molecular hybrids, photosensitizers and heterocycle condensed quinolones.

引用

页码：6009 / 6020

页数：12

共 63 条

[1] Synthesis of Intervenolin, an Antitumor Natural Quino lone with Unusual Substituents [J].

Abe, Hikaru ;

Kawada, Manabu ;

Inoue, Hiroyuki ;

Ohba, Shun-ichi ;

Nomoto, Akio ;

Watanabe, Takumi ;

Shibasaki, Masakatsu .

ORGANIC LETTERS, 2013, 15 (09) :2124-2127

[2]

Ahmed A, 2012, J PHARM PHARM SCI, V15, P52

[3] Novel Substituted Benzothiophene and Thienothiophene Carboxanilides and Quinolones: Synthesis, Photochemical Synthesis, DNA-Binding Properties, Antitumor Evaluation and 3D-Derived QSAR Analysis [J].

Aleksic, Maja ;

Bertosa, Branimir ;

Nhili, Raja ;

Uzelac, Lidija ;

Jarak, Ivana ;

Depauw, Sabine ;

David-Cordonnier, Marie-Helene ;

Kralj, Marijeta ;

Tomic, Sanja ;

Karminski-Zamola, Grace .

JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (11) :5044-5060

[4] 7-((4-Substituted)piperazin-1-yl) derivatives of ciprofloxacin: Synthesis and in vitro biological evaluation as potential antitumor agents [J].

Azema, Joelle ;

Guidetti, Brigitte ;

Dewelle, Janique ;

Le Calve, Benjamin ;

Mijatovic, Tatjana ;

Korolyov, Alexander ;

Vaysse, Julie ;

Malet-Martino, Myriam ;

Martino, Robert ;

Kiss, Robert .

BIOORGANIC & MEDICINAL CHEMISTRY, 2009, 17 (15) :5396-5407

[5] Spectroscopic characterization, photoinduced processes and cytotoxic properties of substituted N-ethyl selenadiazoloquinolones [J].

Barbierikova, Zuzana ;

Bella, Maros ;

Sekerakova, Ludmila ;

Lietava, Jozef ;

Bobenicova, Miroslava ;

Dvoranova, Dana ;

Milata, Viktor ;

Sadecka, Jana ;

Topolska, Dominika ;

Heizer, Tomas ;

Hudec, Roman ;

Czimerova, Adriana ;

Jantova, Sona ;

Brezova, Vlasta .

JOURNAL OF PHYSICAL ORGANIC CHEMISTRY, 2013, 26 (07) :565-574

[6] Photoinduced Superoxide Radical Anion and Singlet Oxygen Generation in the Presence of Novel Selenadiazoloquinolones (An EPR Study) [J].

Barbierikova, Zuzana ;

Bella, Maros ;

Kucerak, Juraj ;

Milata, Viktor ;

Jantova, Sona ;

Dvoranova, Dana ;

Vesela, Maria ;

Stasko, Andrej ;

Brezova, Vlasta .

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 2011, 87 (01) :32-44

[7] Pyrrolo[3,4-h]quinolinones a new class of photochemotherapeutic agents [J].

Barraja, Paola ;

Diana, Patrizia ;

Montalbano, Alessandra ;

Carbone, Anna ;

Viola, Giampietro ;

Basso, Giuseppe ;

Salvador, Alessia ;

Vedaldi, Daniela ;

Dall'Acqua, Francesco ;

Cirrincione, Girolamo .

BIOORGANIC & MEDICINAL CHEMISTRY, 2011, 19 (07) :2326-2341

[8] THE METHODS OF SYNTHESIS, MODIFICATION, AND BIOLOGICAL ACTIVITY OF 4-QUINOLONES (REVIEW) [J].

Boteva, A. A. ;

Krasnykh, O. P. .

CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2009, 45 (07) :757-785

[9] Possible DNA-Interacting Pathways for Metal-Based Compounds Exemplified with Copper Coordination Compounds [J].

Brissos, Rosa F. ;

Caubet, Amparo ;

Gamez, Patrick .

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 2015, (16) :2633-2645

[10] DNA-Dependent Protein Kinase (DNA-PK) Inhibitors. Synthesis and Biological Activity of Quinolin-4-one and Pyridopyrimidin-4-one Surrogates for the Chromen-4-one Chemotype [J].

Cano, Celine ;

Barbeau, Olivier R. ;

Bailey, Christine ;

Cockcroft, Xiao-Ling ;

Curtin, Nicola J. ;

Duggan, Heather ;

Frigerio, Mark ;

Golding, Bernard T. ;

Hardcastle, Ian R. ;

Hummersone, Marc G. ;

Knights, Charlotte ;

Menear, Keith A. ;

Newell, David R. ;

Richardson, Caroline J. ;

Smith, Graeme C. M. ;

Spittle, Ben ;

Griffin, Roger J. .

JOURNAL OF MEDICINAL CHEMISTRY, 2010, 53 (24) :8498-8507

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