Lactobacillus-Deficient Cervicovaginal Bacterial Communities Are Associated with Increased HIV Acquisition in Young South African Women

被引：456

作者：

Gosmann, Christina ^{[1
,2
]}

Anahtar, Melis N. ^{[1
,2
]}

Handley, Scott A. ^{[3
]}

Farcasanu, Mara ^{[1
]}

Abu-Ali, Galeb ^{[4
]}

Bowman, Brittany A. ^{[1
]}

Padavattan, Nikita ^{[5
]}

Desai, Chandni ^{[3
]}

Droit, Lindsay ^{[3
]}

Moodley, Amber ^{[6
]}

Dong, Mary ^{[1
,6
]}

Chen, Yuezhou ^{[2
,7
]}

Ismail, Nasreen ^{[5
]}

Ndung'u, Thumbi ^{[1
,5
]}

Ghebremichael, Musie S. ^{[1
,2
]}

Wesemann, Duane R. ^{[2
,7
]}

Mitchell, Caroline ^{[8
]}

Dong, Krista L. ^{[1
,6
]}

Huttenhower, Curtis ^{[4
]}

Walker, Bruce D. ^{[1
,9
,10
,11
]}

Virgin, Herbert W. ^{[3
]}

Kwon, Douglas S. ^{[1
,2
,10
]}

机构：

[1] Massachusetts Gen Hosp, Ragon Inst MGH MIT & Harvard, Cambridge, MA 02139 USA

[2] Harvard Med Sch, Boston, MA 02115 USA

[3] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA

[4] Harvard Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA

[5] Univ KwaZulu Natal, Nelson R Mandela Sch Med, HIV Pathogenesis Programme, ZA-4001 Durban, Kwazulu Natal, South Africa

[6] Females Rising Educ Support & Hlth, ZA-4066 Durban, Kwazulu Natal, South Africa

[7] Brigham & Womens Hosp, Dept Med, Div Rheumatol Immunol & Allergy, 75 Francis St, Boston, MA 02115 USA

[8] Massachusetts Gen Hosp, Vincent Obstet & Gynecol, Boston, MA 02115 USA

[9] Howard Hughes Med Inst, Chevy Chase, MD 20815 USA

[10] Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02115 USA

[11] MIT, Inst Med Engn & Sci, 77 Massachusetts Ave, Cambridge, MA 02139 USA

来源：

IMMUNITY | 2017年 / 46卷 / 01期

关键词：

T-CELL-ACTIVATION; SEXUAL TRANSMISSION; GENITAL-TRACT; TH17; CELLS; MICROBIOME; IMMUNODEFICIENCY; SUSCEPTIBILITY; INFECTION; SIV; VAGINOSIS;

D O I：

10.1016/j.immuni.2016.12.013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Elevated inflammation in the female genital tract is associated with increased HIV risk. Cervicovaginal bacteria modulate genital inflammation; however, their role in HIV susceptibility has not been elucidated. In a prospective cohort of young, healthy South African women, we found that individuals with diverse genital bacterial communities dominated by anaerobes other than Gardnerella were at over 4-fold higher risk of acquiring HIV and had increased numbers of activated mucosal CD4(+) T cells compared to those with Lactobacillus crispatus- dominant communities. We identified specific bacterial taxa linked with reduced (L. crispatus) or elevated (Prevotella, Sneathia, and other anaerobes) inflammation and HIV infection and found that high-risk bacteria increased numbers of activated genital CD4(+) T cells in a murine model. Our results suggest that highly prevalent genital bacteria increase HIV risk by inducing mucosal HIV target cells. These findings might be leveraged to reduce HIV acquisition in women living in sub-Saharan Africa.

引用

页码：29 / 37

页数：9

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