Synthetic route to alpha-phosphono-gamma-butyrolactones: Synthesis of gamma-substituted alpha-methylene-gamma-butyrolactones

被引：0
作者：
Lee, CW
Gil, JM
Oh, DY
机构：
来源：
HETEROCYCLES | 1997年 / 45卷 / 05期
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中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Treatment of lithiated homoallylic phosphonates with dimethyl carbamyl chloride gave 2-amidophosphonate derivatives. A solution of 2-amidophosphonate in DME-H2O (2:1 vol) reacted with 2 eq. iodine at room temperature to give alpha-phosphono-gamma-iodoalkyl-gamma-butyrolactones in good yield, although the products are mixture. Wadsworth-Emmons reaction of alpha-phosphono-gamma-iodoalkyl-gamma-butyrolactones with aldehydes gave alpha-(alkyl)methylene-gamma-iodoalkyl-gamma-butyro-lactone derivatives.
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页码：943 / 948
页数：6
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