3D HOMOLOGY MODEL OF THE α2C-ADRENERGIC RECEPTOR SUBTYPE

被引：0

作者：

Halip, Liliana ^{[1
]}

Gruia, Alexandra T. ^{[1
]}

Borota, Ana ^{[1
]}

Mracec, Maria ^{[1
]}

Curpan, Ramona F. ^{[1
]}

Mracec, Mircea ^{[1
]}

机构：

[1] Roumanian Acad, Chem Inst Timisoara, RO-300223 Timisoara, Romania

来源：

REVUE ROUMAINE DE CHIMIE | 2012年 / 57卷 / 7-8期

关键词：

omology model; 2RH1 PDB template; GPCR; 3D-model alpha 2C drenergic receptor; PROTEIN-COUPLED RECEPTORS; CRYSTAL-STRUCTURE; ADRENERGIC-RECEPTORS; 3-DIMENSIONAL MODELS; SWISS-MODEL; RHODOPSIN; ENVIRONMENT; MUTAGENESIS; ANTAGONISTS; ACTIVATION;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Comparative modeling of the three-dimensional structure of the human alpha(2C) adrenoceptor (alpha(2C)-AR) based on the high-resolution X-ray structure of the human beta(2)-AR (2RH1, PDB file) is reported. The sequence of the alpha(2C)-AR subtype was aligned with the sequence of the 2RH1 template and the 3D homology model of the alpha(2C)-AR was built using the Modeller software. The stereochemical quality of the 3D homology model was checked by using PROCHECK software and its accuracy was established by docking the endogen ligand, norepinephrine.

引用

页码：763 / 768

页数：6

共 37 条

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