The Mevalonate Auxotrophic Mutant of Staphylococcus aureus Can Adapt to Mevalonate Depletion

被引：5

作者：

Yu, Wenqi ^{[1
]}

Leibig, Martina ^{[1
]}

Schaefer, Tina ^{[2
]}

Bertram, Ralph ^{[1
]}

Ohlsen, Knut ^{[2
]}

Goetz, Friedrich ^{[1
]}

机构：

[1] Univ Tubingen, Interfac Inst Microbiol & Infect Med Tubingen IMI, Tubingen, Germany

[2] Univ Wurzburg, Inst Mol Infect Biol, D-97070 Wurzburg, Germany

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2013年 / 57卷 / 11期

关键词：

BACTERIAL PERSISTENCE; BIOSYNTHESIS; BIOFILMS; ESSENTIALITY; TOLERANCE; EVOLUTION; PATHWAY;

D O I：

10.1128/AAC.00726-13

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In this study, we attempted to adopt the auxotrophic mevalonate synthase mutant (Delta mvaS mutant) of Staphylococcus aureus to study whether a nongrowing but viable cell population is tolerant to bactericidal antibiotics. The mevalonate-depleted nongrowing Delta mvaS mutant was found tolerant to antibiotics. Surprisingly, after prolonged cultivation, we obtained stable Delta mvaS variants that were able to grow without mevalonate, which suggested unknown mechanisms for compensating undecaprenyl pyrophosphate production without mevalonate in S. aureus.

引用

页码：5710 / 5713

页数：4