A Replication Study for Association of ITPKC and CASP3 Two-Locus Analysis in IVIG Unresponsiveness and Coronary Artery Lesion in Kawasaki Disease

被引：34

作者：

Kuo, Ho-Chang ^{[1
,2
]}

Hsu, Yu-Wen ^{[3
,12
]}

Wu, Chung-Min ^{[4
]}

Chen, Shawn Hsiang-Yin ^{[3
]}

Hung, Kuo-Sheng ^{[5
,6
]}

Chang, Wei-Pin ^{[7
]}

Yang, Kuender D. ^{[8
]}

Hsieh, Kai-Sheng ^{[9
]}

Chen, Wei-Chiao ^{[10
]}

Onouchi, Yoshihiro ^{[11
]}

Chang, Wei-Chiao ^{[3
,12
,13
]}

机构：

[1] Kaohsiung Chang Gung Mem Hosp, Dept Pediat, Kaohsiung, Taiwan

[2] Chang Gung Univ, Coll Med, Kaohsiung, Taiwan

[3] Taipei Med Univ, Sch Pharm, Dept Clin Pharm, Taipei, Taiwan

[4] Natl Taipei Univ Technol, Dept Business Management, Taipei 106, Taiwan

[5] Taipei Med Univ, Wan Fang Med Ctr, Ctr Excellence Clin Trial, Taipei, Taiwan

[6] Taipei Med Univ, Wan Fang Med Ctr, Res Grad Inst Injury Prevent & Control, Taipei, Taiwan

[7] Yuanpei Univ, Dept Healthcare Management, Hsinchu, Taiwan

[8] Show Chwan Mem Hosp Chang Bing, Dept Med Res, Changhua, Taiwan

[9] Kaohsiung Vet Gen Hosp, Dept Pediat, Kaohsiung, Taiwan

[10] Natl Cheng Kung Univ, Coll Med, Inst Clin Pharm & Pharmaceut Sci, Tainan 70101, Taiwan

[11] RIKEN, Ctr Genom Med, Lab Cardiovasc Dis, Yokohama, Kanagawa, Japan

[12] Taipei Med Univ, Sch Pharm, Master Program Clin Pharmacogen & Pharmacoprote, Taipei, Taiwan

[13] Taipei Med Univ, Wanfang Hosp, Dept Pharm, Taipei, Taiwan

来源：

PLOS ONE | 2013年 / 8卷 / 07期

关键词：

INTRAVENOUS IMMUNOGLOBULIN TREATMENT; GENOME-WIDE ASSOCIATION; TREATMENT FAILURE; GAMMA-GLOBULIN; SUSCEPTIBILITY; LOCUS; POLYMORPHISMS; CHILDREN; THERAPY; YOUNG;

D O I：

10.1371/journal.pone.0069685

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Single-nucleotide polymorphisms (SNPs) in inositol 1,4,5-trisphosphate 3-kinase C (ITPKC, rs28493229) and caspase-3 (CASP3, rs113420705) are associated with susceptibility to KD in Japanese and Taiwanese populations. This study was conducted to investigate the involvement of these 2 SNPs in the risk for intravenous immunoglobulin (IVIG) resistance and coronary artery lesion (CAL) in Taiwanese population. A total of 340 KD patients were subjected to assess by the identification of 2-locus genes model. A combinatorial association between ITPKC (rs28493229) and CASP3 (rs113420705) was found in CAL formation (P = 0.0227, OR: 3.06). KD patients with high-risk genotype had a trend of overrepresentation in IVIG resistance compared with individual SNPs. Our findings suggest the existence of genetic factors affecting patients' risk for CAL formation and IVIG responsiveness in a Taiwanese population.

引用

页数：5

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