Rosiglitazone suppresses gastric carcinogenesis by up-regulating HCaRG expression

被引：13

作者：

Chen, Bai-Li ^{[3
]}

Yu, Jun ^{[2
]}

Zeng, Zhi-Rong ^{[3
]}

Chu, Wai-Kit ^{[2
]}

Wong, Christine Y. P. ^{[2
]}

Cheng, Yuen-Yee ^{[2
]}

Sung, Joseph J. Y. ^{[2
]}

Hu, Pin-Jin ^{[3
]}

Leung, Wai K. ^{[1
,2
]}

机构：

[1] Chinese Univ Hong Kong, Dept Med & Therapeut, Inst Digest Dis, Shatin, Hong Kong, Peoples R China

[2] Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Shatin, Hong Kong, Peoples R China

[3] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Gastroenterol, Guangzhou 510275, Guangdong, Peoples R China

来源：

ONCOLOGY REPORTS | 2008年 / 20卷 / 05期

关键词：

rosiglitazone; peroxisome proliferator-activated receptors;

D O I：

10.3892/or_00000114

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Our previous study demonstrated that PPAR gamma ligand rosiglitazone prevents gastric carcinogenesis in rats induced by chemical carcinogen N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). In this study, we attempted to identify novel anticancer mechanisms of rosiglitazone. By examining the gene expression profiles of MNNG-induced and rosiglitazone-treated gastric cancer with Uniset Rat I Bioarray microarray, we identified a gene that showed prominent responses in the rosiglitazone-treated group. The hypertension-related, calcium-regulated gene (HCaRG) was significantly up-regulated in rat gastric carcinoma of the rosiglitazone-treated group when compared with the MNNG group. We further examined HCaRG expression in human gastric cancer and found that the expression of HCaRG was down-regulated in human gastric cancerous tissue. Rosiglitazone markedly induced the expression of HCaRG in the AGS cell line. The up-regulation of HCaRG may be one of the mechanisms underlying the chemopreventive effect of rosiglitazone in gastric cancer.

引用

页码：1093 / 1097

页数：5

共 28 条

[11] Chemoprevention of gastric cancer by celecoxib in rats [J].

Hu, PJ ;

Yu, J ;

Zeng, ZR ;

Leung, WK ;

Lin, HL ;

Tang, BD ;

Bai, AHC ;

Sung, JJY .

GUT, 2004, 53 (02) :195-200

[12] 15-Deoxy-Δ12,14-prostaglandin J2 inhibits G2-M phase progression in human breast cancer cells via the down-regulation of cyclin B1 and survivin expression [J].

Kamagata, Chinatsu ;

Tsuji, Naoki ;

Moriai, Mikako ;

Kobayashi, Daisuke ;

Watanabe, Naoki .

BREAST CANCER RESEARCH AND TREATMENT, 2007, 102 (03) :263-273

[13] Ciglitazone induces caspase-independent apoptosis through down-regulation of XIAP and survivin in human glioma cells [J].

Kang, Dong Wan ;

Choi, Chang Hwa ;

Park, Ji Yeon ;

Kang, Soo Kyung ;

Kim, Yong Keun .

NEUROCHEMICAL RESEARCH, 2008, 33 (03) :551-561

[14] Peroxisome proliferator-activated receptor-γ activator 15-deoxy-Δ12,14-prostaglandin J2 inhibits neuroblastoma cell growth through induction of apoptosis:: Association with extracellular signal-regulated kinase signal pathway [J].

Kim, EJ ;

Park, KS ;

Chung, SY ;

Sheen, YY ;

Moon, DC ;

Song, YS ;

Kim, KS ;

Song, S ;

Yun, YP ;

Lee, MK ;

Oh, KW ;

Yoon, DY ;

Hong, JT .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2003, 307 (02) :505-517

[15] Apoptotic action of peroxisome proliferator-activated receptor-γ activation in human non-small-cell lung cancer is mediated via proline oxidase-induced reactive oxygen species formation [J].

Kim, Ki Young ;

Ahn, Jin Hee ;

Cheon, Hyae Gyeong .

MOLECULAR PHARMACOLOGY, 2007, 72 (03) :674-685

[16] Anti-inflammatory effect of antidiabetic thiazolidinediones prevents bone resorption rather than cartilage changes in experimental polyarthritis [J].

Koufany, Meriem ;

Moulin, David ;

Bianchi, Arnaud ;

Muresan, Mikhaela ;

Sebillaud, Sylvie ;

Netter, Patrick ;

Weryha, Georges ;

Jouzeau, Jean-Yves .

ARTHRITIS RESEARCH & THERAPY, 2008, 10 (01)

[17]

Leung WK, 2006, GASTROENTEROLOGY, V130, pA9

[18] Chemoprevention of gastric cancer [J].

Leung, Wai K. ;

Sung, Joseph J. Y. .

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 2006, 18 (08) :867-871

[19] Effect of peroxisome proliferator activated receptor γ ligands on growth and gene expression profiles of gastric cancer cells [J].

Leung, WK ;

Bai, AHC ;

Chan, VYW ;

Yu, J ;

Chan, MWY ;

To, KF ;

Wu, JR ;

Chan, KK ;

Fu, YG ;

Chan, FKL ;

Sung, JJY .

GUT, 2004, 53 (03) :331-338

[20] Peroxisome proliferator-activated receptor-gamma Pro12Ala polymorphism, Helicobacter pylori infection and non-cardia gastric carcinoma in Chinese [J].

Liao, SY ;

Zeng, ZR ;

Leung, WK ;

Zhou, SZ ;

Chen, B ;

Sung, JJY ;

Hu, PJ .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2006, 23 (02) :289-294

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