Corticosterone modulates fear responses and the expression of glucocorticoid receptors in the brain of high-anxiety rats

被引：12

作者：

Wislowska-Stanek, A. ^{[1
]}

Lehner, M. ^{[2
]}

Skorzewska, A. ^{[2
]}

Maciejak, P. ^{[1
,2
]}

Szyndler, J. ^{[1
]}

Turzynska, D. ^{[2
]}

Sobolewska, A. ^{[2
]}

Plaznik, A. ^{[1
,2
]}

机构：

[1] Med Univ Warsaw, Dept Expt & Clin Pharmacol, PL-00927 Warsaw, Poland

[2] Inst Psychiat & Neurol, Dept Neurochem, PL-02957 Warsaw, Poland

来源：

NEUROSCIENCE LETTERS | 2013年 / 533卷

关键词：

Conditioned freezing; Corticosterone; Glucocorticoid receptors; Prefrontal cortex; Dentate gyrus; High- and low-anxiety rats; POSTTRAUMATIC-STRESS-DISORDER; C-FOS EXPRESSION; D-CYCLOSERINE; AMYGDALA; GABA; PROJECTIONS; MIDAZOLAM; SUBUNITS; BEHAVIOR; CORTEX;

D O I：

10.1016/j.neulet.2012.11.012

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The aim of our experiments was to assess the effect of acutely administered corticosterone on the expression of glucocorticoid receptors (GRs) in the brain of rats with high (HR) and low (LR) levels of anxiety. The rats were divided into groups according to their conditioned fear-induced freezing responses and then were subjected to a second conditioned fear session one week after the initial fear conditioning. Immunocytochemical analysis revealed that the second exposure to contextual aversive stimuli resulted in higher levels of GRs expression in cingulate cortex area 1 (Cg1), the secondary motor cortex (M2) of the prefrontal cortex and the dentate gyrus of the hippocampus (DG) in LR rats compared with HR rats. The pretreatment of HR rats with corticosterone (20 mg/kg, sc) increased the expression levels of GRs in Cg1, the M2 area and the DG to the levels observed in the LR vehicle group. The increase in the GRs levels was accompanied by a significant decrease in the conditioned fear response in the HR group. The control animals that were not exposed to aversive stimuli had similar levels of receptor-related immunoreactivity in all brain regions, and corticosterone did not change these expression levels. Our results suggest that HR animals may have deficits in the expression of stress-induced GRs in the prefrontal cortex and the DG. In addition, pretreatment with corticosterone increases the expression of GRs and normalizes the fear response in HR rats. (c) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：17 / 22

页数：6

共 26 条

[1] Block of glucocorticoid synthesis during re-activation inhibits extinction of an established fear memory [J].

Blundell, Jacqueline ;

Blaiss, Cory A. ;

Lagace, Diane C. ;

Eisch, Amelia J. ;

Powell, Craig M. .

NEUROBIOLOGY OF LEARNING AND MEMORY, 2011, 95 (04) :453-460

[2] Paradoxical effects of chronic corticosterone on forced swim behaviours in aged male and female rats [J].

Brotto, LA ;

Gorzalka, BB ;

Barr, AM .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2001, 424 (03) :203-209

[3] Blunted HPA axis response to stress influences susceptibility to posttraumatic stress response in rats [J].

Cohen, Hagit ;

Zohar, Joseph ;

Gidron, Yori ;

Matar, Michael A. ;

Belkind, Dana ;

Loewenthal, Uri ;

Kozlovsky, Nitsan ;

Kaplan, Zeev .

BIOLOGICAL PSYCHIATRY, 2006, 59 (12) :1208-1218

[4] Glucocorticoids for the treatment of post-traumatic stress disorder and phobias: A novel therapeutic approach [J].

de Quervain, Dominique J. -F. ;

Margraf, Juergen .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2008, 583 (2-3) :365-371

[5] Glucocorticoids enhance extinction-based psychotherapy [J].

de Quervain, Dominique J. -F. ;

Bentz, Dorothee ;

Michael, Tanja ;

Bolt, Olivia C. ;

Wiederhold, Brenda K. ;

Margraf, Juergen ;

Wilhelm, Frank H. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (16) :6621-6625

[6] Initial posttraumatic urinary cortisol levels predict subsequent PTSD symptoms in motor vehicle accident victims [J].

Delahanty, DL ;

Raimonde, AJ ;

Spoonster, E .

BIOLOGICAL PSYCHIATRY, 2000, 48 (09) :940-947

[7] Glucocorticoid receptor number predicts increase in amygdala activity after severe stress [J].

Geuze, Elbert ;

van Wingen, Guido A. ;

van Zuiden, Mirjam ;

Rademaker, Arthur R. ;

Vermetten, Eric ;

Kavelaars, Annemieke ;

Fernandez, Guillen ;

Heijnen, Cobi J. .

PSYCHONEUROENDOCRINOLOGY, 2012, 37 (11) :1837-1844

[8]

Herman JP, 1998, J NEUROSCI, V18, P7462

[9] Central mechanisms of stress integration: hierarchical circuitry controlling hypothalamo-pituitary-adrenocortical responsiveness [J].

Herman, JP ;

Figueiredo, H ;

Mueller, NK ;

Ulrich-Lai, Y ;

Ostrander, MM ;

Choi, DC ;

Cullinan, WE .

FRONTIERS IN NEUROENDOCRINOLOGY, 2003, 24 (03) :151-180

[10] Anatomical analysis of afferent projections to the medial prefrontal cortex in the rat [J].

Hoover, Walter B. ;

Vertes, Robert P. .

BRAIN STRUCTURE & FUNCTION, 2007, 212 (02) :149-179

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