Molecular Mechanisms and Function Prediction of Long Noncoding RNA

被引：83

作者：

Ma, Handong ^{[1
]}

Hao, Yun ^{[1
]}

Dong, Xinran ^{[1
]}

Gong, Qingtian ^{[1
]}

Chen, Jingqi ^{[1
]}

Zhang, Jifeng ^{[1
]}

Tian, Weidong ^{[1
]}

机构：

[1] Fudan Univ, Inst Biostat, Sch Life Sci, Shanghai 2004333, Peoples R China

来源：

SCIENTIFIC WORLD JOURNAL | 2012年

基金：

中国国家自然科学基金;

关键词：

GENOME-WIDE IDENTIFICATION; XIST RNA; GENE; TRANSCRIPTION; CHROMATIN; ANNOTATION; EXPRESSION; REVEAL; REPRESSION; GENERATION;

D O I：

10.1100/2012/541786

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The central dogma of gene expression considers RNA as the carrier of genetic information from DNA to protein. However, it has become more and more clear that RNA plays more important roles than simply being the information carrier. Recently, whole genome transcriptomic analyses have identified large numbers of dynamically expressed long noncoding RNAs (lncRNAs), many of which are involved in a variety of biological functions. Even so, the functions and molecular mechanisms of most lncRNAs still remain elusive. Therefore, it is necessary to develop computational methods to predict the function of lncRNAs in order to accelerate the study of lncRNAs. Here, we review the recent progress in the identification of lncRNAs, the molecular functions and mechanisms of lncRNAs, and the computational methods for predicting the function of lncRNAs.

引用

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