Association of IL-6 gene polymorphism with the outcome of allogeneic haematopoietic stem cell transplantation in Czech patients

被引：14
作者：
Ambruzova, Z.
Mrazek, F.
Raida, L. [2 ]
Faber, E. [2 ]
Onderkova, J.
Kriegova, E.
Indrak, K. [2 ]
Petrek, M. [1 ]
机构：
[1] Univ Hosp, Tissue Typing Lab, Dept Immunol, Palacky Univ Olomouc, Olomouc 77520, Czech Republic
[2] Univ Hosp Olomouc, Dept Haematooncol, Olomouc, Czech Republic
来源：
INTERNATIONAL JOURNAL OF IMMUNOGENETICS | 2008年 / 35卷 / 4-5期
关键词：
D O I：
10.1111/j.1744-313X.2008.00798.x
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Interleukin-6 (IL-6) is an important pro-inflammatory mediator implicated in immune-mediated complications of allogeneic haematopoietic stem cell transplantation (aHSCT). In accord with previous reports, this preliminary study on 56 donor-recipient pairs revealed IL-6-174 single nucleotide polymorphisms as a risk factor for the development of acute graft-versus-host disease and decreased survival after aHSCT.
引用
收藏
页码：401 / 403
页数：3
相关论文
共 9 条
[1]   Phototyping: Comprehensive DNA typing for HLA-A, B, C, DRB1, DRB3, DRB4, DRB5 & DQB1 by PCR with 144 primer mixes utilizing sequence-specific primers (PCR-SSP) [J].
Bunce, M ;
ONeill, CM ;
Barnardo, MCNM ;
Krausa, P ;
Browning, MJ ;
Morris, PJ ;
Welsh, KI .
TISSUE ANTIGENS, 1995, 46 (05) :355-367
[2]   Interferon-γ and interleukin-6 gene polymorphisms associate with graft-versus-host disease in HLA-matched sibling bone marrow transplantation [J].
Cavet, J ;
Dickinson, AM ;
Norden, J ;
Taylor, PRA ;
Jackson, GH ;
Middleton, PG .
BLOOD, 2001, 98 (05) :1594-1600
[3]  
DICKINSON AM, 2005, CURRENT OPINION IMMU, V17, P1
[4]   The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis [J].
Fishman, D ;
Faulds, G ;
Jeffery, R ;
Mohamed-Ali, V ;
Yudkin, JS ;
Humphries, S ;
Woo, P .
JOURNAL OF CLINICAL INVESTIGATION, 1998, 102 (07) :1369-1376
[5]   IL-6 and IL-10 promoter gene polymorphisms of patients and donors of allogeneic sibling hematopoietic stem cell transplants associate with the risk of acute graft-versus-host disease [J].
Karabon, L ;
Wysoczanska, B ;
Bogunia-Kubik, K ;
Suchnicki, K ;
Lange, A .
HUMAN IMMUNOLOGY, 2005, 66 (06) :700-710
[6]   Donor cytokine genotype influences the development of acute rejection after renal transplantation [J].
Marshall, SE ;
McLaren, AJ ;
McKinney, EF ;
Bird, TG ;
Haldar, NA ;
Bunce, M ;
Morris, PJ ;
Welsh, KI .
TRANSPLANTATION, 2001, 71 (03) :469-476
[7]   Beyond HLA: the significance of genomic variation for allogeneic hematopoietic stem cell transplantation [J].
Mullally, Ann ;
Ritz, Jerome .
BLOOD, 2007, 109 (04) :1355-1362
[8]   Non-HLA immunogenetic polymorphisms and the risk of complications after allogeneic hemopoietic stem-cell transplantation [J].
Mullighan, C ;
Heatley, S ;
Doherty, K ;
Szabo, F ;
Grigg, A ;
Hughes, T ;
Schwarer, A ;
Szer, J ;
Tait, B ;
To, B ;
Bardy, P .
TRANSPLANTATION, 2004, 77 (04) :587-596
[9]   Both genetic and clinical factors predict the development of graft-versus-host disease after allogeneic hematopoietic stem cell transplantation [J].
Socié, G ;
Loiseau, P ;
Tamouza, R ;
Janin, A ;
Busson, M ;
Gluckman, E ;
Charron, D .
TRANSPLANTATION, 2001, 72 (04) :699-706
1